摘要
目的本研究旨在探究多西他赛复合聚甲基丙烯酸甲酯(PMMA)骨水泥体外理化性质变化,确定最佳多西他赛浓度配方。方法通过按标准比例混合骨水泥粉剂(PalacosLV)与多西他赛(0.25%~2.00%)制备样品,采用成型、力学性能测试、显微结构观察、药物释放及细胞毒性测试等方法展开研究。结果多西他赛的添加对骨水泥机械性能有一定影响,1%以内浓度添加与PMMA+0.00%(control)浓度比较差异无统计学意义(P>0.05);显微结构观察显示不同浓度多西他赛在骨水泥基质中分散情况不同;药物释放测试表明1%多西他赛组在各时间点累积释放量最高;细胞毒性测试评估了不同处理条件下骨水泥的细胞毒性。结论1%多西他赛复合骨水泥在机械性能、药物释放等方面表现最佳,有望在肿瘤局部提供化疗作用,改善种植体骨整合和患者预后,但研究存在一定局限性,未来需进一步深入探索。
【Objective】This study aimed to investigate the changes in the physicochemical properties of docetaxel-composite PMMA bone cement in vitro and determine the optimal docetaxel concentration formula.【Methods】Samples were prepared by mixing bone cement powder(Palacos LV)with docetaxel(0.25%~2.00%)at a standard ratio.The research was carried out through molding,mechanical property testing,microstructure observation,drug release testing,and cell cytotoxicity testing.【Results】The addition of docetaxel had a certain impact on the mechanical properties of bone cement.There was no significant difference between the addition of docetaxel at a concentration of 1%or less and the PMMA group.Microstructure observation showed different dispersion of docetaxel at different concentrations in the bone cement matrix.The drug release test indicated that the cumulative release amount of the 1%docetaxel group was the highest at each time point.The cell cytotoxicity test assessed the cytotoxicity of bone cement under different treatment conditions.【Conclusion】The 1%docetaxel-composite bone cement showed the best performance in terms of mechanical properties and drug release.It is expected to provide local chemotherapy for tumors,improve thce osseointegration of implants and patient prognosis.However,there are certain limitations in the study,and further in-depth exploration is needed in the future.
作者
毕玥
王克
邹康
BI Yue;WANG Ke;ZOU Kang(Department of Orthopedics and Orthopedic Oncology,Yantai Mountain Hospital,Yantai,Shandong 264003,China)
出处
《中国医学工程》
2025年第8期31-36,共6页
China Medical Engineering
基金
2022年度科技创新发展计划项目(2022YD045)。
关键词
多西他赛
骨水泥
力学性能
药物释放
承载能力
docetaxel
bone cement
mechanical properties
drug release
bearing capability
