摘要
目的利用温度场和磁场辅助的微流控液滴技术,合成了一种具有温度响应特性的多模运动微米机器人(MMMR),实现药物靶向递送和药物释放范围控制。方法通过将明胶与磁性微米颗粒混合后利用微流控液滴技术合成MMMR,在合成装置的设计中加入了温度场和磁场进行辅助,实现了机器人的磁各向异性结构。通过旋转均匀磁场控制MMMR沿预设路径进行大范围运动,并利用不同频率的平面旋转梯度磁场驱动MMMR进行局部圆周运动。MMMR装载模拟药物,通过加热进行药物释放。结果在垂直于平面旋转磁场的驱动下,MMMR可以实现直线运动,完成规定路径的运动。且在平面梯度旋转磁场作用下,MMMR利用旋转产生的离心力,可以实现运动半径可调的圆周运动。装载模拟药物的MMMR在磁场引导下成功到达目标位置,通过激光加热(39℃)融化明胶基质,精准释放药物,药物释放后,自组装的磁颗粒作为一个整体被移除。结论MMMR具备多模态运动能力,可实现规定路径精准导航,并能够在局部动态调控药物释放范围,具有广泛的生物医学应用潜力。
Objective To synthesize a temperature-responsive multimodal motion microrobot(MMMR)using temperature and magnetic field-assisted microfluidic droplet technology to achieve targeted drug delivery and controlled drug release.Methods Microfluidic droplet technology was utilized to synthesize the MMMR by mixing gelatin with magnetic microparticles.The microrobot possessed a magnetic anisotropy structure to allow its navigation and targeted drug release by controlling the temperature field and magnetic field.In the experiment,the MMMR was controlled to move in a wide range along a preset path by rotating a uniform magnetic field,and the local circular motion was driven by a planar rotating gradient magnetic field of different frequencies.The MMMR was loaded with simulated drugs,which were released in response to laser heating.Results Driven by a rotating magnetic field,the MMMR achieved linear motion following a predefined path.The planar gradient rotating magnetic field controlled circular motion of the MMMR with an adjustable radius,utilizing the centrifugal force generated by rotation.The drug-loaded MMMR successfully reached the target location under magnetic guidance,where the gelatin matrix was melted using laser heating for accurate drug release,after which the remaining magnetic particles were removed using magnetic field.Conclusion The MMMR possesses multimodal motion capabilities to enable precise navigation along a predefined path and dynamic regulation of drug release within the target area,thus having great potential for a wide range of biomedical applications.
作者
赵旭辉
刘梦然
陈曦
黄静
刘源
徐海峰
ZHAO Xuhui;LIU Mengran;CHEN Xi;HUANG Jing;LIU Yuan;XU Haifeng(Hubei Provincial Key Laboratory of Modern Manufacture Quality Engineering,Hubei University of Technology,Wuhan 430068,China;Institute of Biomedical and Health Engineering,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology),Nanjing University of Posts and Telecommunications,Nanjing 210023,China)
出处
《南方医科大学学报》
北大核心
2025年第8期1758-1767,共10页
Journal of Southern Medical University
基金
国家自然科学基金(52303167,52203152)
湖北省自然科学基金(2022CFB473)
广东省普通高校重点领域专项项目(2022ZDZX3047)。
关键词
药物递送
微米机器人
磁各向异性
多模运动
微流控合成
drug delivery
microrobot
magnetic anisotropy
multimodal motion
microfluidic synthesis
