摘要
脓毒症是由宿主感染应答失调引发的临床综合征,以早期过度炎症与后期免疫抑制为特征,中性粒细胞在此过程中发挥至关重要的作用。精氨酸酶1(Arg-1)作为一种在免疫调节和代谢过程中发挥关键作用的酶,在脓毒症血浆及中性粒细胞中的表达和活性发生显著变化,能够调控中性粒细胞功能,共同介导脓毒症免疫抑制。但目前关于这方面的研究较少,具体机制尚未阐明。现对Arg-1在脓毒症炎症与免疫调节中的作用、Arg-1在中性粒细胞中的表达调控及其对中性粒细胞功能的影响以及相关分子机制研究进展进行系统综述,为深入理解Arg-1在脓毒症免疫抑制中的作用提供参考,为脓毒症的治疗提供新的思路和方向。
Sepsis is a clinical syndrome triggered by dysregulation of the host’s response to infection,characterized by early hyperinflammation and late immunosuppression,in which neutrophils play a key role.Arginase 1(Arg-1),an enzyme that plays a key role in immunomodulation and metabolism,is significantly altered in expression and activity in sepsis plasma as well as in neutrophils,and is able to modulate neutrophil function,which collectively mediates sepsis immunosuppression.But few studies have been conducted in this area,and the specific mechanisms have not yet been elucidated.This article systematically reviews the research progress of the role of Arg-1 in inflammation and immune regulation in sepsis,the expression regulation of Arg-1 in neutrophils and its effect on neutrophil function,and the related molecular mechanisms,so as to provide a reference for further understanding the role of Arg-1 in immunosuppression in sepsis,and provide new ideas and directions for the treatment of sepsis.
作者
罗何娇
邓烈华
张媛莉
LUO Hejiao;DENG Liehua;ZHANG Yuanli(Department of Critical Care Medicine,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,China)
出处
《陕西医学杂志》
2025年第9期1270-1274,共5页
Shaanxi Medical Journal
基金
国家自然科学基金资助项目(82172148)
创新药物上市后临床科研专项课题(WKZX2024CX301205)。
