摘要
目的 描述北京市妊娠期高血压(GH)患者头发样本中邻苯二甲酸酯(PAEs)浓度水平,探究重要生活方式和居住状况与PAEs暴露的关联性。方法 本研究数据来源于北京大学生育健康研究所与北京市海淀区妇幼保健院合作开展的孕期队列,于2017年10月至2018年10月募集并完成2 731名孕妇的随访工作,经一定纳入排除标准筛选后,最终纳入206名GH患者作为研究对象。基线时通过面对面问卷调查收集研究对象的一般特征、生活方式和居住状况等信息并采集头发样本,通过医院电子病历系统进行随访。采用气相色谱-三重四级杆串联质谱仪(GC-MS/MS)测定头发样本中12种PAEs的浓度。采用中位数和四分位数描述各PAEs组分浓度的分布特征,应用Logistic回归模型探究重要生活方式和居住状况因素与PAEs暴露水平之间的关联。结果 北京市GH患者头发样本中12种PAEs的检出率均达70%以上,其中邻苯二甲酸二(2-乙基已基)酯[DEHP]暴露水平最高,头发中浓度中位数为7 770.2 ng/g。调整年龄与孕前身体质量指数(BMI)后,GH患者近1月内下厨做饭每周1次以上与较高水平的邻苯二甲酸二烯丙酯(DAP)之间存在显著关联,调整比值比(OR)=2.52[95%置信区间(CI),1.17~5.44];不使用化妆品与较低水平的邻苯二甲酸双(2-甲氧基乙)酯[DMEP]显著关联,调整后OR=0.28(95%CI,0.09~0.87);近1年内家中装修与较高水平的DMEP显著关联,调整后OR=3.09(95%CI,1.24~7.68)。结论 12种PAEs组分在北京市GH患者头发中普遍检出,其中DEHP暴露水平最高。多种生活方式和居住状况与特定PAEs组分暴露水平之间存在关联,下厨房做饭、家中装修分别是DAP和DMEP暴露的危险因素,不使用化妆品可能是减少DMEP暴露的保护因素。
Objective To describe phthalate(PAEs)concentrations in hair samples and explore the association between life behaviors and living conditions with hair concentrations of PAEs among participants with gestational hypertension(GH)in Beijing,China.Methods This study was based on the pregnancy cohort established by Beijing Haidian District Maternal and Child Health Hospital and the Institute of Reproductive and Child Health at Peking University.2,731 pregnant women were recruited and completed follow-up from October 2017 to October 2018.According to the specific inclusion and exclusion standardization,a total of 206 GH women were included as participants in this study.We collected hair samples and baseline data on general characteristics,life behaviors and living conditions through questionnaires;we obtained follow-up data through the hospital′s electronic medical record system.12 components of PAEs in hair samples were detected by gas chromatography-coupled triple quadrupole mass spectrometry(GC-MS/MS).The median and quartiles were applied to characterize the distribution of PAEs concentrations,and logistic regression model was applied to explore the association between life behaviors and living conditions with PAEs levels.Results The detection rates of 12 PAEs in hair samples were more than 70%.The highest hair concentration was found in bis(2-ethylhexyl)phthalate(DEHP),with a median hair concentration of 7770.2 ng/g.Cooking in the kitchen more than once a week in the last month was significantly associated with a higher level of diallyl phthalate(DAP)in hair among GH women(adjusted OR=2.52,95%CI:1.17-5.44);not using cosmetics was significantly associated with a lower level of bis(2-methoxyethyl)phthalate(DMEP)in hair(adjusted OR=0.28,95%CI:0.09-0.87);and home decoration in the last 1 year was significantly associated with a higher level of DMEP in hair(OR=3.09,95%CI:1.24-7.68).Conclusion PAEs were commonly detected in the hair of GH women in Beijing,of which DEHP showed the highest concentration of 12 components.We found significant associations between various life behaviors and living conditions and specific PAEs exposures.Cooking in the kitchen and home decoration might be risk factors for exposure to DAP and DMEP,respectively.Not using cosmetics might be a protective factor to reduce exposure to DMEP.
作者
刘晓雯
杨泽平
任梦圆
贾晓倩
陈俊熹
高素红
刘晓红
张乐
叶荣伟
李智文
李楠
LIU Xiaowen;YANG Zeping;REN Mengyuan;JIA Xiaoqian;CHEN Junxi;GAO Suhong;LIU Xiaohong;ZHANG Le;YE Rongwei;LI Zhiwen;LI Nan(Institute of Reproductive and Child Health/Key Laboratory of Reproductive Health,National Health Commission of the People′s Republic of China,Department of Epidemiology and Biostatistics,School of Public Health,Peking University Health Science Center,Beijing 100191,PR China)
出处
《中国生育健康杂志》
2025年第5期407-412,424,共7页
Chinese Journal of Reproductive Health
基金
国家自然科学基金(81903327,82173527,81673177)
北京市自然科学基金(7194285,7222245,7234401)
中国博士后科学基金(88014Y0226)。
