摘要
透析相关淀粉样变性(DRA)是维持性血液透析(MHD)的远期并发症,严重影响患者的生活及透析质量。目前DRA仍以预防为主,缺少有效治疗,常用透析模式(如高通量血液透析及血液透析滤过)疗效不确定。延展性血液透析(HDx)是一种使用中截留量膜的新型血液透析模式,经济成本低于血液透析滤过,可以更好地清除β2微球蛋白(β2-MG)等中大分子毒素,改善MHD患者的微炎症状态,为预防DRA提供理论依据。本文拟就DRA的发病机制,以及HDx治疗DRA的理论依据和优势进行综述。
Dialysis-related amyloidosis is a long-term complication of maintenance hemodialysis,Serious affect the quality of life and dialysis of MHD patients,The treatment should focus on prevention,and Lack of effective treatment,Common dialysis such as high-flux hemodialysis and hemodiafiltration have uncertain therapeutic effects.expanded hemodialysis(HDx)is a novel hemodialysis,it use medium cut-off membranes.The economic cost is lower than hemodiafiltration.It can better remove medium and large molecular toxins such asβ2-MG and improve the micro-inflammatory state of MHD patients,providing a theoretical basis for the prevention of DRA.This article reviews the pathogenesis of dialysis-related amyloidosis,And was conducted on the theoretical basis and advantages of HDx in treating DRA.
作者
马雪
王勾琴(综述)
孔玉科(审校)
MA Xue;WANG Gouqin;KONG Yuke(Department of Nephrology,Gansu Provincial Clinical Medical Research Center for Kidney Diseases,The Second Hospital of Lanzhou University,Lanzhou 730030,China)
出处
《肾脏病与透析肾移植杂志》
2025年第4期386-390,共5页
Chinese Journal of Nephrology,Dialysis & Transplantation
