摘要
目的探讨前列腺癌(PC)组织中核受体相互作用蛋白2(NRIP2)、双特异性磷酸酶14(DUSP14)表达水平及与患者病理特征、预后的关系。方法选取2019年5月至2021年5月上海理工大学附属市东医院收治的106例PC患者作为研究对象,检测患者癌组织和癌旁组织NRIP2、DUSP14表达情况,分析NRIP2、DUSP14表达与PC病理特征的关系;随访3年,采用多因素Cox回归分析探讨PC患者预后的影响因素。结果PC患者癌组织NRIP2的阳性表达率为68.91%,高于癌旁组织的28.30%;癌组织DUSP14的阳性表达率为27.36%,低于癌旁组织的66.98%,差异均有统计学意义(P均<0.05)。NRIP2阳性、DUSP14阴性患者的TNM分期ⅢA期占比、术前PSA水平>20 ng/mL占比、Gleason评分>7分占比高于NRIP2阴性、DUSP14阳性患者,差异均有统计学意义(P<0.05)。106例PC患者出院后连续随访3年,29例患者肿瘤进展,患者3年无进展生存率为72.64%(77/106)。TNM分期Ⅰ~Ⅱ期、Gleason评分≤7分、NRIP2阴性、DUSP14阳性患者的3年无进展生存率高于TNM分期ⅢA期、Gleason评分>7分、NRIP2阳性、DUSP14阴性患者,差异均有统计学意义(P均<0.05)。TNM分期ⅢA期、Gleason评分>7分、NRIP2阳性、DUSP14阴性是PC患者预后的独立危险因素(P<0.05)。结论PC组织中NRIP2呈高表达,DUSP14呈低表达,两指标表达水平与TNM分期、术前PSA水平、Gleason评分及预后相关。
Objective To explore the expression of nuclear receptor interacting protein 2(NRIP2)and dual specificity phosphatase 14(DUSP14)in prostate cancer(PC)and their correlation with pathological features and prognosis.Methods 106 PC patients admitted to Shanghai University of Technology Affiliated Shidong Hospital from May 2019 to May 2021 were selected as the research subjects.The expression of NRIP2 and DUSP14 in the cancer tissue group and adjacent tissues of the patients was detected,and the relationship be⁃tween NRIP2 and DUSP14 expression and the pathological characteristics of PC was analyzed by chi square test.They were followed up for 3 years,and multivariate Cox regression analysis was used to explore the factors af⁃fecting the prognosis of PC patients.Results The positive expression rate of NRIP2 in PC tissues was 68.91%,which was higher than the 28.30%in paracancerous tissues.The positive expression rate of DUSP14 in cancer tissues was 27.36%,which was lower than the 66.98%in adjacent tissues(all P<0.05).The proportion of TNM stageⅢA,preoperative PSA level>20 ng/mL,and Gleason score>7 in NRIP2 positive and DUSP14 negative patients were higher than those in NRIP2 negative and DUSP14 positive patients,and the differences were statis⁃tically significant(P<0.05).A total of 106 PC patients were followed up for 3 years after discharge,29 patients had tumor progression,and the 3⁃year progression⁃free survival rate of the patients was 72.64%(77/106).The 3⁃year progression⁃free survival rate of patients with TNM stageⅠ~Ⅱ,Gleason score≤7,NRIP2 negative and DUSP14 positive was higher than that of patients with TNM stageⅢA,Gleason score>7,NRIP2 positive and DUSP14 negative(all P<0.05).TNM stageⅢA,Gleason score>7,NRIP2 positive and negative DUSP14 were independent risk factors for the prognosis of PC patients(P<0.05).Conclusions The expression of NRIP2 is high and DUSP14 is low in PC tissues.The expression level of NRIP2 is correlated with TNM stage,preoperative PSA level,Gleason score and prognosis.
作者
高雯雯
赵泰
陆晓俊
崔樟丽
彭丽霞
GAO Wenwen;ZHAO Tai;LU Xiaojun;CUI Zhangli;PENG Lixia(Department of Oncology,Shidong hospital,Affiliated to University of Shanghai for Science and Technology,Shanghai,China,200438;Department of Urology,Shanghai Fourth People's Hospital,School of Medicine,Tongji University,Shanghai,China,200434)
出处
《分子诊断与治疗杂志》
2025年第8期1476-1479,共4页
Journal of Molecular Diagnostics and Therapy
基金
上海市杨浦区卫生健康委员会科研课题计划项目(YPO202315)。
关键词
前列腺癌
核受体相互作用蛋白2
双特异性磷酸酶14
预后
Prostate cancer
Nuclear receptor interacting protein 2
Dual⁃specificity phosphatase 14
Prognosis
