摘要
目的:探讨萎缩性胃炎(AG)患者影像学特征与血清生物标志物水平的相关性。方法:纳入130例确诊的胃炎患者为研究对象,根据内镜及病理活检结果将患者分为对照组(非萎缩性胃炎患者,n=71)和观察组(萎缩性胃炎患者,n=59)。观察组患者根据萎缩严重程度又分为轻度萎缩组(n=23)、中度萎缩组(n=24)和重度萎缩组(n=12)。分析AG患者影像学特征及其严重程度与胃泌素17(G-17)、胃蛋白酶Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、降钙素原(PCT)、白细胞介素6(IL-6)、白细胞介素17(IL-17)、干扰素γ(IFN-γ)、抗肿瘤坏死因子α(TNF-α)水平、转化生长因子β1(TGF-β1)水平的相关性。结果:AG患者PCT、IL-6、IL-17、TGF-β1水平均升高(P<0.001),G-17和PGⅠ水平均下降(P<0.001);PCT、IL-6和TGF-β1水平均与AG的严重程度正相关(P<0.001),G-17和PGⅠ水平则负相关(P<0.001),PGⅠ和PCT水平为AG严重程度的独立影响因素(P<0.05)。结论:PCT、IL-6、IL-17、TGF-β1水平均随AG严重程度而升高,而G-17和PGⅠ水平则均随AG严重程度而下降,PGⅠ和PCT水平为AG严重程度的独立影响因素。
Objective:To explore the correlation between radiological characteristics and serum biomarker levels in patients with atrophic gastritis(AG).Methods:130 gastritis patients were selected as the subjects.Based on endoscopic and pathological biopsy results,they were divided into a control group(non-atrophic gastritis patients,n=71)and an observation group(atrophic gastritis patients,n=59).The observation group was further divided into mild atrophy group(n=23),moderate atrophy group(n=24),and severe atrophy group(n=12).The correlation between the imaging features and severity of AG and the levels of gastrin 17(G-17),pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),procalcitonin(PCT),interleukin-6(IL-6),interleukin-17(IL-17),interferon-γ(IFN-γ),tumor necrosis factor(TNF-α),and transforming growth factorβ1(TGF-β1)were analyzed.Results:AG patients had increased levels of PCT,IL-6,IL-17,and TGF-β1(P<0.001),while G-17 and PG levels were decreased(P<0.001).PCT,IL-6,and TGF-β1 levels were positively correlated with the severity of AG(P<0.001),while G-17 and PG levels showed a negative correlation(P<0.001).PG I and PCT levels were independent factors affecting the severity of AG(P<0.05).Conclusion:PCT,IL-6,IL-17,and TGF-β1 levels are positively correlated with the occurrence of AG,while G-17 and PG levels are negatively correlated.PG I and PCT levels are independent factors affecting the severity of AG.
作者
赖小斌
郑艳梅
段晋灵
张宇
LAI Xiao-bin;ZHENG Yan-mei;DUAN Jin-ling;ZHANG Yu(Department of Internal Medicine IV,Chongzhou Hospital of Traditional Chinese Medicine,Chengdu 611230;Department of Gastroenterology,Chengdu First People's Hospital,Chengdu 610000;Department of Internal Medicine I,Chongzhou Hospital of Traditional Chinese Medicine,Chengdu 611230,Sichuan,China)
出处
《川北医学院学报》
2025年第8期1070-1074,共5页
Journal of North Sichuan Medical College
