摘要
目的:探讨奥马珠单抗联合丙酸氟替卡松治疗儿童过敏性哮喘(AA)的疗效。方法:选取100例AA患儿为研究对象,按照治疗方式不同将患儿分为对照组与观察组,每组各50例。对照组予以丙酸氟替卡松治疗;观察组予以奥马珠单抗联合丙酸氟替卡松治疗,两组均治疗4个月。记录并比较两组患儿治疗前后儿童哮喘控制测试(C-ACT)和哮喘日间、夜间症状评分,检测患儿肺功能指标[第1秒用力呼气量(FEV1)、最大呼气流量(PEF)]和血清免疫球蛋白E(IgE)、C反应蛋白(CRP)、白细胞介素6(IL-6)、转化生长因子β1(TGF-β1)、基质金属蛋白酶9(MMP-9)水平。记录并比较两组患儿疗效。结果:观察组治疗总有效率为94.00%,高于对照组的80.00%(P<0.05)。治疗后,与对照组相比,观察组C-ACT评分和FEV1、PEF更高(P<0.05),哮喘日间、夜间评分更低(P<0.05)。治疗后,观察组血清IgE、CRP和IL-6、TGF-β1、MMP-9水平均低于对照组(P<0.05)。结论:在丙酸氟替卡松治疗基础上,加用奥马珠单抗能够缓解AA患儿哮喘症状,降低炎症水平,抑制气道重塑,改善患儿肺功能。
Objective:To investigate the efficacy of omalizumab combined with fluticasone propionate in the treatment of allergic asthma(AA)in children.Methods:A total of 100 AA children were divided into control group and observation group according to different treatment methods,with 50 cases in each group.The control group was treated with fluticasone propionate,and the observation group was treated with omalizumab combined with fluticasone propionate.Both groups were treated for 4 months.Children's Asthma Control Test(C-ACT),daytime and nighttime symptom scores of asthma were recorded before and after treatment in the two groups.Lung function[forced expiratory volume in the first second(FEV1),maximum expiratory flow(PEF)]and serum immunoglobulin E(IgE),C-reactive protein(CRP),interleukin-6(IL-6),transforming growth factor-β1(TGF-β1)and matrix metalloproteinase-9(MMP-9)levels were detected.The therapeutic effects were recorded and compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group(94.00%vs.80.00%,P<0.05).After treatment,compared with the control group,the C-ACT score,FEV1 and PEF in the observation group were higher(P<0.05),and the daytime and nighttime scores of asthma were lower(P<0.05).After treatment,the levels of serum IgE,CRP,IL-6,TGF-β1 and MMP-9 in the observation group were lower than those in the control group(P<0.05).Conclusion:On the basis of fluticasone propionate treatment,the addition of omalizumab can relieve asthma symptoms,reduce inflammation levels,inhibit airway remodeling,and improve lung function in children with AA.
作者
罗慧
郭双
陈晶晶
LUO Hui;GUO Shuang;CHEN Jing-jing(Department of Pediatrics,Hubei Jianghan Oilfield General Hospital,Qianjiang 433100;Department of Laboratory,Hubei Jianghan Oilfield General Hospital,Qianjiang 433100;Department of Clinical Laboratory,Wuhan Sixth Hospital Affiliated to Jianghan University,Wuhan 430014,Hubei,China)
出处
《川北医学院学报》
2025年第8期1030-1034,共5页
Journal of North Sichuan Medical College
基金
湖北省武汉市中医药科研项目(WZ22Z03)。
关键词
过敏性哮喘
儿童
丙酸氟替卡松
奥马珠单抗
炎症
肺功能
气道重塑
Allergic asthma
Children
Fluticasone propionate
Omalizumab
Inflammation
Lung function
Airway remodeling
