摘要
强直性脊柱炎是一种慢性炎症性疾病,炎症、骨破坏和新骨形成是典型的病理变化。由于致病机制尚未完全明确,因此治疗难度较大。随着医学的快速发展,现代医学采用白细胞介素17抑制剂和肿瘤坏死因子抑制剂为强直性脊柱炎的治疗提供新的前景。研究发现,中药通过调控强直性脊柱炎相关信号通路,可以抑制炎症反应、氧化应激,调节成骨细胞和破骨细胞之间的平衡以及免疫反应,最终达到治疗强直性脊柱炎的目的。近年来,中医药防治强直性脊柱炎备受关注,从中药调控相关信号通路治疗强直性脊柱炎展开研究,总结归纳中药防治强直性脊柱炎的作用机制,为治疗强直性脊柱炎提供新的思路。
Ankylosing spondylitis is a chronic inflammatory disease in which inflammation,bone destruction and new bone formation are the typical pathologic changes.Since its pathogenic mechanism has not been completely clarified,it is difficult to treat.With the rapid development of medicine,western medicine has provided new prospects for the treatment of ankylosing spondylitis by using interleukin 17 inhibitors and tumor necrosis factor inhibitors.Meanwhile,it has been found that Chinese medicine can inhibit inflammatory response,inhibit oxidative stress,regulate the balance between osteoblasts and osteoclasts,and regulate immune response by modulating the signaling pathway related to ankylosing spondylitis,and ultimately achieve the purpose of treating ankylosing spondylitis.In recent years,the prevention and treatment of ankylosing spondylitis by traditional Chinese medicine has attracted much attention.Based on this,this paper will study the modulation of relevant signaling pathways by TCM to treat ankylosing spondylitis.This paper will summarize the mechanism of action of traditional Chinese medicine in the treatment of ankylosing spondylitis,and provide new ideas for the future treatment of ankylosing spondylitis in the field of medicine.
作者
张循儒
张邦能
李红专
刘跃振
张效收
Zhang Xunru;Zhang Bangneng;Li Hongzhuan;Liu Yuezhen;Zhang Xiaoshou(Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu ProvincialHospital of TCM,Lanzhou 730050,China)
出处
《亚太传统医药》
2025年第7期226-231,共6页
Asia-Pacific Traditional Medicine
基金
甘肃省重点研发计划项目(21YF5FA025)
甘肃省中医药科研项目(GZKP-2023-4)。
关键词
强直性脊柱炎
中药
信号通路
研究进展
Ankylosing Spondylitis
Traditional Chinese Medicine
Signalling Pathways
Research Progress
