摘要
目的探究成人腺垂体功能减退症(hypopituitarism,HP)患者住院期间代谢综合征(metabolic syndrome,MS)患病现状及其影响因素。方法收集2021年3月至2024年3月在新疆医科大学第一附属医院治疗的成人HP患者信息,统计成人HP患者MS患病情况,采用logistic回归分析影响成人HP患者患MS的影响因素。结果该研究308例成人HP患者有121例患者发生MS,187例患者未发生MS,分别纳入MS组(n=148)和非MS组(n=232)。成人HP患者发生MS的几率为38.95%(148/380);与非MS组相比,MS组患者高密度脂蛋白胆固醇、血清总胆固醇、低密度脂蛋白胆固醇水平更高、腰围更大、生长激素水平更低(P<0.05);logistic回归分析结果显示,高密度脂蛋白胆固醇(OR=1.069,95%CI:1.010~1.132,P=0.021)、血清总胆固醇(OR=1.065,95%CI:1.014~1.119,P=0.012)、低密度脂蛋白胆固醇(OR=1.055,95%CI:1.005~1.108,P=0.031)、腰围(OR=1.063,95%CI:1.006~1.123,P=0.030)、生长激素(OR=1.077,95%CI:1.019~1.138,P=0.009)能够独立影响成人HP患者发生MS(P<0.05)。结论住院期间成人HP患者常合并MS,高密度脂蛋白胆固醇、血清总胆固醇、低密度脂蛋白胆固醇、腰围、生长激素是影响成人HP患者发生MS的因素。
Objective To investigate the prevalence status and influencing factors of metabolic syndrome(MS)in adult patients with hypopituitarism(HP)during hospitalization.Methods The data of adult HP patients who received treatment in the hospital were collected from March 2021 to March 2024.The prevalence status of MS in adult HP patients was counted,and logistic regression analysis was adopted to analyze the influencing factors of MS in adult HP patients.Results Among the 308 adult HP patients in this study,121 cases developed MS and 187 cases did not develop MS,and they were included in the MS group(n=148)and the non-MS group(n=232).The incidence of MS in adult HP patients was 38.95%(148/380).Compared with the non-MS group,the levels of high-density lipoprotein cholesterol,serum total cholesterol and low-density lipoprotein cholesterol in the MS group were higher,the waist circumference was larger,and the growth hormone was lower(P<0.05).After logistic regression analysis,it was found that high-density lipoprotein cholesterol(OR=1.069,95%CI:1.010-1.132,P=0.021),total serum cholesterol(OR=1.065,95%CI:1.014-1.119,P=0.012),low-density lipoprotein cholesterol(OR=1.055,95%CI:1.005-1.108,P=0.031),waist circumference(OR=1.063,95%CI:1.006-1.123,P=0.030)and growth hormone(OR=1.077,95%CI:1.019-1.138,P=0.009)could independently affect the occurrence of MS in adult HP patients(P<0.05).Conclusion Adult HP patients during hospitalization are often complicated with MS.High-density lipoprotein cholesterol,serum total cholesterol,low-density lipoprotein cholesterol,waist circumference,and growth hormone are factors affecting the occurrence of MS in adult HP patients.
作者
姜丽娜
徐静
史超
张瑞华
JIANG Lina;XU Jing;SHI Chao;ZHANG Ruihua(Department of Endocrinology,the First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830054,China)
出处
《公共卫生与预防医学》
2025年第5期121-124,共4页
Journal of Public Health and Preventive Medicine
