摘要
目的:探讨老年人非酒精性脂肪肝病(NAFLD)和超重/肥胖的交互作用对轻度认知障碍(MCI)患病风险的影响。方法:本研究为横断面研究,基于湖北老年记忆队列(HMACS),采用整群随机抽样方法抽取2018—2023年武汉市5661例≥65岁老年人作为研究对象,收集其全套标准化神经心理评估及临床体检结果,采用腹部超声诊断NAFLD,采用logistic回归模型分析NAFLD和超重/肥胖与MCI的关联性,采用相乘和相加模型分析二者交互作用对MCI患病风险的影响。结果:纳入分析的5661例老年人中,男性2563例,女性3098例,年龄(72.24±5.51)岁,2239例(39.6%)居住在农村,2841例(50.2%)存在超重/肥胖,2390例(42.2%)患有NAFLD,1694例(29.9%)患有MCI。有NAFLD且超重/肥胖者患MCI的风险是无NAFLD且非超重/肥胖者的2.975倍(OR=2.975,95%CI:2.489~3.557,P<0.001)。NAFLD和超重/肥胖对MCI存在相乘交互作用(OR=1.508,95%CI:1.169~1.944,P=0.002);NAFLD和超重/肥胖对MCI存在相加交互作用,其相对超额危险度、交互作用归因比和交互作用指数分别为1.099(95%CI:0.630~1.593)、0.369(95%CI:0.222~0.487)、2.256(95%CI:1.457~3.492)。结论:老年人NAFLD和超重/肥胖存在交互作用,两者同时存在时MCI患病风险增加。
Objective To investigate the interaction between non-alcoholic fatty liver disease(NAFLD)and overweight/obesity on the risk of mild cognitive impairment(MCI)in elderly individuals.MethodsThis cross-sectional study was based on the Hubei Memory and Aging Cohort Study(HMACS).Cluster random sampling was used to select 5661 elderly individuals aged≥65 years in Wuhan from 2018 to 2023.Standardized neuropsychological assessments and clinical examinations results were collected.The NAFLD was diagnosed by abdominal ultrasound.The logistic regression analysis was used to analyze the association of NAFLD and overweight/obesity with MCI.The impacts of interaction between NAFLD and overweight/obesity on the risk of MCI were analyzed using both multiplicative and additive models.ResultsAmong the 5661 elderly individuals included in the analysis,2563 were male and 3098 were female,with a mean age of(72.24±5.51)years.A total of 2239 participants(39.6%)resided in rural areas,2841(50.2%)were overweight/obesity,2390(42.2%)had NAFLD,and 1694(29.9%)were diagnosed with MCI.The risk of MCI in elderly individuals with NAFLD and overweight/obesity was 2.975 times(OR=2.975,95%CI:2.489-3.557,P<0.001)of that in non-overweight/obese individuals without NAFLD.There was a multiplicative interaction between NAFLD and overweight/obesity on MCI(OR=1.508,95%CI:1.169-1.944,P=0.002).NAFLD and overweight/obesity had an additive interaction effect on the risk of MCI,and the relative excess risk of interaction,attributable proportion of interaction and the synergy index was 1.099(95%CI:0.630-1.593),0.369(95%CI:0.222-0.487),2.256(95%CI:1.457-3.492),respectively.ConclusionThere is an interaction between NAFLD and overweight/obesity in elderly individuals,and the co-existence of NAFLD and overweight/obesity increases the risk of MCI in this population.
作者
蔡婉莹
许浪
李弈晴
李春利
黄静
瞿秀
Cai Wanying;Xu Lang;Li Yiqing;Li Chunli;Huang Jing;Qu Xiu(School of Nursing,Medical College,Wuhan University of Science and Technology,Hubei Provincial Clinical Research Center for Alzheimer′s Disease,Brain Science and Advanced Technology Institute,Wuhan University of Science and Technology,Wuhan 430065,China;Nursing Department,PuRen Hospital Affiliated to Wuhan University of Science and Technology,Wuhan 430081,China)
出处
《中华健康管理学杂志》
北大核心
2025年第8期611-616,共6页
Chinese Journal of Health Management
基金
国家自然科学基金(72174159)。
关键词
老年人
非酒精性脂肪肝病
超重/肥胖
轻度认知障碍
交互作用
Elderly
Non-alcoholic fatty liver disease
Overweight/obesity
Mild cognitive impairment
Interactions
