摘要
目的收集非酒精性脂肪肝患者的临床资料,并探讨影响其严重程度的相关危险因素。方法选取2020年1月至2022年12月本院收治的非酒精性脂肪肝患者的临床和实验室检查结果,对比分析轻度、中度及重度非酒精性脂肪肝患者在血常规、肝肾功能、血清电解质、血糖、血脂及肿瘤指标方面的差异,并对影响非酒精性脂肪肝患者严重程度的危险因素进行Logistic回归分析。结果三组患者的血清尿酸(P=0.002)、空腹血糖(P=0.006)及甘油三酯(P=0.001)水平差异有统计学意义。多因素Logistic回归分析显示,血清尿酸(OR=1.002,95%CI:1.001~1.004,P=0.002)、空腹血糖(OR=1.001,95%CI:1.000~1.003,P=0.038)、甘油三酯(OR=1.202,95%CI:1.101~1.314,P<0.001)是非酒精性脂肪肝患者严重程度的显著影响因素。结论血清尿酸、空腹血糖及甘油三酯是影响非酒精性脂肪肝患者严重程度的重要危险因素。
Objective To collect clinical data of patients with non-alcoholic fatty liver disease(NAFLD)and explore the risk factors affecting its severity.Methods Clinical and laboratory data of NAFLD patients admitted to our hospital from January 2020 to December 2022 were analyzed.Differences in blood routine tests,liver and kidney function,serum electrolytes,blood sugar,blood lipids,and serum tumor markers among mild,moderate,and severe groups of NAFLD patients were compared.Logistic regression analysis was performed to identify risk factors affecting the severity of NAFLD.Results Significant differences were found in serum uric acid(P=0.002),fasting blood glucose(P=0.006),and triglycerides(P=0.001)among the three groups.Multivariate logistic regression analysis indicated that serum uric acid(OR=1.002,95%CI:1.001~1.004,P=0.002),fasting blood glucose(OR=1.001,95%CI:1.000~1.003,P=0.038),and triglycerides(OR=1.202,95%CI:1.101~1.314,P<0.001)were significant risk factors for the severity of NAFLD.Conclusion Serum uric acid,fasting blood glucose,and triglycerides are important risk factors affecting the severity of NAFLD.
出处
《浙江临床医学》
2025年第2期241-242,246,共3页
Zhejiang Clinical Medical Journal
关键词
非酒精性脂肪肝
严重程度
危险因素
Non-alcoholic fatty liver disease
Severity
Risk factors
