摘要
目的探讨三黄紫草膏联合硫辛酸对糖尿病足(DF)创面修复及血清炎症、疼痛因子及氧化应激指标水平的影响。方法选取2022年1月至2023年12月河北省沧州中西医结合医院收治的90例DF患者,按照完全随机法分为对照组(给予硫辛酸+利凡诺外敷治疗,45例)和观察组(给予硫辛酸+三黄紫草膏外用治疗,45例)。对比两组患者治疗前(T_(0))、治疗后21 d(T_(1))创面愈合情况、炎症及疼痛因子、中医证候积分、氧化应激指标、临床疗效及安全性。结果观察组的总有效率高于对照组(P<0.05)。T_(1)时刻两组患者患侧足部创面面积、创面pH值、白细胞介素(IL)-6、IL-18、降钙素原(PCT)、基质金属蛋白酶(MMP-2)水平及中医证候积分均较T_(0)时刻降低,且观察组低于对照组(P<0.05)。T_(1)时刻两组患者患侧足部创面氧分压、五羟色胺(5-HT)、β-内啡肽(β-EP)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-PX)水平均较T_(0)时刻升高,且观察组高于对照组(P<0.05)。两组安全性指标比较,差异无统计学意义(P>0.05)。结论采用三黄紫草膏与硫辛酸治疗DF患者,可抑制炎症因子,调节氧化应激反应,减轻疼痛,促进创面修复,临床疗效显著,且安全可靠,值得在临床进一步推广应用。
Objective To investigate the effects of Sanhuang Zicao ointment combined with lipoic acid on wound repair,as well as the levels of serum inflammatory factors,pain factors and oxidative stress indices in patients with diabetic foot(DF).Methods Ninety DF patients admitted to Cangzhou Integrated Traditional Chinese and Western Medicine Hospital of Hebei Province from January 2022 to December 2023 were randomly assigned into a control group(treated with lipoic acid+rivanol external application,45 patients)and an observation group(treated with lipoic acid+Sanhuang Zicao ointment external application,45 patients).The wound healing,inflammation and pain factors,traditional Chinese medicine syndrome scores,oxidative stress indicators,clinical efficacy,and safety were compared between the two groups before treatment(T_(0))and 21 days after treatment(T_(1)).Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).At T_(1),the wound area of the affected foot,wound pH value,interleukin-6(IL-6),IL-18,procalcitonin(PCT),matrix metalloproteinase(MMP-2)levels,and traditional Chinese medicine syndrome score in both groups were significantly reduced compared to T_(0),and the observation group was lower than the control group(P<0.05).At T_(1),the oxygen partial pressure,5-hydroxytryptamine(5-HT),β-endorphin(β-EP),superoxide dismutase(SOD),catalase(CAT),and glutathione peroxidase(GSH-PX)levels in the affected foot wounds of both groups were significantly increased compared to T_(0),and the observation group was higher than the control group(P<0.05).There were no significant differences in safety indicators between the two groups(P>0.05).Conclusion Treatment of DF patients with Sanhuang Zicao ointment and lipoic acid can inhibit inflammatory factors,regulate oxidative stress,relieve pain,and promote wound healing.It showed significant clinical efficacy,was safe and reliable,and is worthy of further clinical promotion and application.
作者
赵铭坤
王猛
ZHAO Mingkun;WANG Meng(Endocrinology Department,Cangzhou Integrated Traditional Chinese and Western Medicine Hospital,Cangzhou,Hebei 061000,China)
出处
《转化医学杂志》
2025年第7期150-154,共5页
Translational Medicine Journal
基金
河北省中医药管理局科研计划项目(2024466)。
