摘要
目的 探讨加味桃核承气汤治疗脓毒症胃肠功能障碍的临床效果。方法 纳入2022年1月-2024年1月河北省沧州中西医结合医院收治的198例脓毒症胃肠功能障碍患者,随机分为对照组(常规西医治疗)与观察组(联合加味桃核承气汤),治疗1周。评估2组胃肠功能障碍积分、APACHE评分、SOFA评分、腹围、肠鸣音、腹内压、炎症指标(CRP、IL-6、SAA、PCT)及胃肠功能指标(胃泌素-17、胃蛋白酶I/II)的变化,并比较总有效率与安全性。结果 治疗后,观察组胃肠功能障碍积分、APACHE评分、SOFA评分、腹围、腹内压及炎症指标降幅均大于对照组(P<0.05);肠鸣音及胃肠功能指标升幅更高(P<0.05);观察组总有效率92.93%显著高于对照组73.74%(P<0.05);2组均无不良反应。结论 加味桃核承气汤可通过抑制炎症反应、修复肠道屏障改善脓毒症胃肠功能障碍,疗效显著且安全。
Objective To evaluate the efficacy of modified Taohe Chengqi Decoction(MTCD)in the treatment of sepsis-induced gastrointestinal dysfunction.Methods A total of 198 patients with sepsis-induced gastrointestinal dysfunction were randomized into a control group(with conventional western medicine treatment)and an observation group(combined with modified Taohe Chengqi Decoction).Both groups received the corresponding treatment for one week.The changes in the gastrointestinal dysfunction scores,APACHE scores,SOFA scores,abdominal circumference,bowel sounds,intra-abdominal pressure,inflammatory markers(CRP,IL-6,SAA,PCT),and gastrointestinal function indicators(gastrin-17,pepsin I/ll)in the two groups were evaluated,and their total effective rates and safety were compared.Results After treatment,the observation group showed a greater decrease in the gastrointestinal dysfunction scores,APACHE scores,SOFA scores,abdominal circumference,intra-abdominal pressure,and inflammatory markers compared to the control group(P<0.05),while the increase in bowel sounds and the gastrointestinal function indicators was significantly higher(P<0.05).The total effective rate was 92.93%in the observation group,significantly higher than that in the control group(73.74%)(P<0.05).Both groups had no adverse reactions.Conclusion Modified Taohe Chengqi Decoction can improve gastrointestinal dysfunction in patients with sepsis by inhibiting inflammatory reactions and repairing intestinal barriers,with a significant therapeutic effect and safety.
作者
申建国
王健
张亮
陈羽
SHEN Jianguo;WANG Jian;ZHANG Liang;CHEN Yu(Department of Intensive Care Medicine,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Cangzhou 061001,China;Department of Traditional Chinese Medicine,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Cangzhou 061001,China;Department of Critical Care Pediatrics,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Cangzhou 061001,China)
出处
《吉林中医药》
2025年第8期931-935,共5页
Jilin Journal of Chinese Medicine
基金
河北省中医药管理局科研计划项目(2020471)。
关键词
脓毒症
胃肠功能障碍
加味桃核承气汤
炎症因子
胃泌素-17
sepsis
gastrointestinal dysfunction
modified Taohe Chengqi Decoction
inflammatory factors
gastrin-17
