摘要
目的探讨穴位埋线联合外源性生长激素(GH)治疗多囊卵巢综合征(PCOS)患者的临床效果及对颗粒细胞凋亡、体外受精-胚胎移植(IVF-ET)结局的影响。方法选取2022年6月至2023年6月河北省沧州中西医结合医院收治的90例行IVF-ET的PCOS不孕患者作为研究对象,采用随机数字表法分为对照组和联合组,每组45例。对照组采用外源性GH治疗,联合组采用外源性GH联合穴位埋线治疗。比较两组的治疗效果、子宫情况、颗粒细胞凋亡率、IVF-ET结局指标及不良反应发生情况。结果联合组总有效率显著高于对照组,差异具有统计学意义(P<0.05);联合组胚胎种植率、活产率、子宫内膜厚度、临床妊娠率显著高于对照组,卵巢体积、颗粒细胞凋亡率显著低于对照组,差异具有统计学意义(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论PCOS患者采用穴位埋线联合外源性GH治疗可显著提升临床疗效,改善IVF-ET结局指标,减少颗粒细胞凋亡,安全性高。
Objective To investigate the clinical effect of acupoint embedding combined with exogenous growth hormone(GH)in the treatment of polycystic ovary syndrome(PCOS)patients and its impact on granular cell apoptosis and in vitro fertilization-embryo transfer(IVF-ET)outcomes.Methods A total of 90 PCOS patients who underwent IVF-ET in Cangzhou Hospital of integrated traditional Chinese and Western medicine from June 2022 to June 2023 were selected as research subjects and were grouped into control group and combined group by random number table method,with 45 cases in each group.The control group received exogenous GH treatment,while the combined group received exogenous GH combined with acupoint embedding therapy.The treatment effect,uterine condition,granular cell apoptosis rate,IVF-ET outcome indicators,and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the combined group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).The embryo implantation rate,live birth rate,endometrial thickness,and clinical pregnancy rate of the combined group were significantly higher than those of the control group,while the ovarian volume and granular cell apoptosis rate were significantly lower than those of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in comparing the occurrence of adverse reactions between the two groups(P>0.05).Conclusions PCOS patients receiving acupoint embedding combined with exogenous GH can significantly improve the clinical efficacy,improve IVF-ET outcome indicators,reduce granular cell apoptosis,and has high safety.
作者
李小玉
郝镁娟
王蒙娜
王慧君
LI Xiaoyu;HAO Meijuan;WANG Mengna;WANG Huijun(Department of Reproductive Medicine Second,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Hebei Province,Cangzhou 061001,Hebei,China)
出处
《中国性科学》
2025年第8期113-117,共5页
Chinese Journal of Human Sexuality
基金
河北省中医药管理局科研计划项目(2022223)。
关键词
多囊卵巢综合征
穴位埋线
生长激素
颗粒细胞
Polycystic ovary syndrome
Acupoint embedding
Growth hormone
Granular cells
