摘要
急性髓系白血病(AML)是常见的急性白血病亚型之一,其发病机制复杂,临床预后差,治愈率低。肠道微生物群在维持宿主免疫稳态、调节炎症反应以及影响肿瘤发生发展中发挥关键作用。肠道菌群失衡与AML的发生、发展密切相关。肠道菌群失衡可能是精准治疗AML的重要靶点,解析肠道菌群失衡与AML的关系对AML的临床治疗有重要意义。本文旨在综述近年来肠道菌群失衡与AML相关性的研究进展,探讨其在AML发病机制中的潜在作用。
Acute myeloid leukemia(AML)is one of the common subtypes of acute leukemia,characterized by complex pathogenesis,poor clinical prognosis,and low cure rate.The gut microbiota plays a crucial role in maintaining host immune homeostasis,regulating inflammatory responses,and influencing tumor initiation and progression.Gut microbiota dysbiosis is closely associated with the occurrence and development of AML.It may serve as an important target for precision treatment of AML.Understanding the relationship between gut microbiota dysbiosis and AML is of great significance for the clinical management of AML.This review aimed to summarize recent research progress in the correlation between gut microbiota dysbiosis and AML and explore its potential role in the pathogenesis of AML.
作者
王利
王科进
WANG Li;WANG Kejin(Department of Hematology,Chengdu Shangjin Nanfu Hospital,Chengdu,Sichuan,610000)
出处
《实用临床医药杂志》
2025年第13期145-148,共4页
Journal of Clinical Medicine in Practice
基金
四川省中医药管理局科学技术研究课题(2021MS171)。
关键词
急性髓系白血病
肠道菌群失衡
发病机制
预后
治愈率
靶点
精准治疗
研究进展
acute myeloid leukemia
gut microbiota dysbiosis
pathogenesis
prognosis
cure rate
target
precision treatment
research progress
