摘要
肠道微生物群是机体不可或缺的新的“功能器官”,而肠道菌群是其重要的组成部分。研究显示多种慢性肝病均存在肠道菌群的失衡,而调整肠道菌群有利于肝病的康复。药物性肝损伤(drug-induced liver injury,DILI)是一种常见的肝病,研究显示肠道菌群的变化参与了多种DILI的发生过程。本文就药物对肠道菌群的影响、DILI中肠道菌群变化、肠道菌群变化对DILI的影响及靶向于肠道菌群的DILI的诊断及治疗策略进行阐述,以期为合理有效地治疗或预防DILI提供参考。
Intestinal microbiota is an indispensable new“functional organ”of the body,and intestinal microbiota is an important part of it.Researches have indicated that intestinal microbiota imbalance exists in several chronic liver diseases,and the modulation of intestinal microbiota is conducive to the rehabilitation of liver conditions.Drug-induced liver injury(DILI)is a common liver disease.Studies have demonstrated that alterations in intestinal microbiota are implicated in the occurrence and development of DILI.In this article,the effects of drugs on intestinal microbiota,the influence of the intestinal microbiota in DILI,and the diagnosis and treatment strategies of DILI targeting intestinal microbiota are reviewed,which will provide references for the treatment or prevention of DILI.
作者
李艳
师安怡
邢卉春
Li Yan;Shi Anyi;Xing Huichun(Center of Liver Diseases,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China)
出处
《中国医学前沿杂志(电子版)》
北大核心
2025年第6期28-33,共6页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
国家重点研发计划(2022YFC2304500)
北京市科技计划(Z221100007422002)
国家重点研发计划(2021YFC2301800)
首都卫生发展科研专项(首发2024-1-2181)
肝胆相照公益基金(iGandanF-1082023-GSH011)。
关键词
肠道菌群
药物性肝损伤
诊断
治疗
Intestinal microbiota
Drug-induced liver injury
Diagnosis
Treatment
