摘要
目的探讨犀角地黄汤联合中药灌肠对脓毒症患者肾功能、凝血功能及血清炎症因子的影响。方法选择2020年10月—2022年10月中山大学附属第八医院收治的105例脓毒症患者进行研究,根据治疗方法分两组,对照组(50例)给予西药治疗,观察组(55例)在对照组基础上给予犀角地黄汤联合中药灌肠治疗,7 d为1个疗程,两组均治疗4个疗程。治疗4个疗程后,比较两组疗效,记录治疗前后肾功能指标[肌酐(Scr)、尿素氮(urea nitrogen,BUN)]、凝血功能指标[活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、凝血酶原时间(prothrombin time,PT)、D-二聚体(D-dimer,D-D)、纤维蛋白原(fibrinogen,FIB)]及血清炎症因子指标[肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、C反应蛋白(C-reactive protein,CRP)、白细胞介素-8(interleukin-8,IL-8)]变化,并统计两组的不良反应。结果观察组总有效率为90.91%(50/55),高于对照组的76.00%(38/50),差异有统计学意义(P<0.05)。治疗后,观察组的Scr、BUN水平低于对照组,差异有统计学意义(P<0.05);治疗后,观察组的FIB水平高于对照组,D-D、PT、APTT水平低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组的TNF-α、CRP、IL-6水平低于对照组,差异有统计学意义(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论犀角地黄汤联合中药灌肠可改善患者的肾功能、凝血功能,减轻炎症反应,促进疾病康复,效果显著,且不会增加不良反应,可在临床推广运用。
Objective To explore the effects of Xijiao Dihuang Decoction(犀角地黄汤)combined with traditional Chinese medicine enema on renal function,coagulation function and serum inflammatory factors in patients with sepsis.Methods A total of 105 patients with sepsis admitted to the The Eighth Affiliated Hospital,Sun Yat-sen University from October 2020 to October 2022 were selected for the study.According to the treatment method,the control group(50 cases)was treated with Western medicine,while the observation group(55 cases)was treated with Xijiao Dihuang Decoction combined with traditional Chinese medicine enema on the basis of the control group,7 d was a course of treatment,and both groups were treated for 4 courses.After 4 courses of treatment,the therapeutic effects of the two groups were compared,and the changes in renal function indicators[creatinine(Scr),urea nitrogen(BUN)],coagulation function indicators[activated partial thromboplastin time(APTT),prothrombin time(PT),D-dimer(D-D),fibrinogen(FIB)],and serum inflammatory factor indicators[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-8(IL-8)]were recorded before and after treatment,and the adverse reactions in both groups were recorded.Results The total effective rate of the observation group was 90.91%(50/55),which was higher than that 76.00%(138/50)of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of Scr and BUN in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the FIB value of the observation group was higher than that of the control group,while the values of D-D,PT and APTT were lower than those of the control group,with statistical significance(P<0.05).After treatment,the levels of TNF-α,CRP,and IL-6 in the observation group were significantly lower than those in the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of Xijiao Dihuang Decoction and traditional Chinese medicine enema can improve the renal function and coagulation function of patients and reduce inflammatory reactions,promote disease recovery,and has a significant effect,which will not increase adverse reactions and can be promoted and applied in clinical practice.
作者
王宇辰
黄凡
李浩
黄晨达
WANG Yuchen;HUANG Fan;LI Hao;HUANG Chenda(The Eighth Affiliated Hospital,Sun Yat-sen University,Shenzhen 518033,Guangdong,China)
出处
《辽宁中医杂志》
北大核心
2025年第8期108-111,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
广东省中医药管理局课题(20181062)。
关键词
脓毒症
犀角地黄汤
中药灌肠
肾功能
凝血功能
炎症因子
sepsis
Xijiao Dihuang Decoction(犀角地黄汤)
Chinese medicine enema
renal function
coagulation function
inflammatory factors
