摘要
轻度创伤性脑损伤(mild traumatic brain injury,mTBI)占创伤性脑损伤(traumatic brain injury,TBI)病例总数的80%以上,是常见的神经系统疾病之一。然而目前关于mTBI的诊断及创伤后的认知功能改变所潜在的神经生理机制尚不确切,影响mTBI的早期诊断、治疗决策及预后评价。近年来越来越多的多模态磁共振成像(magnetic resonance imaging,MRI)技术应用于mTBI的诊断,包括功能磁共振成像(functional magnetic resonance imaging,fMRI)、动脉自旋标记示踪法(arterial spin labeling,ASL)灌注成像、磁敏感加权成像(susceptibility-weighted imaging,SWI)、扩散张量成像(iffusion tensor imaging,DTI),并基于不同的角度增进了对mTBI神经病理学机制的理解。本文综述上述多模态MRI技术在mTBI上的应用进展,并对其优缺点进行评价,为今后研究提供新思路。
Mild traumatic brain injury(mTBI)accounts for over 80%of all traumatic brain injury(TBI)cases and is one of the common neurological disorders.However,the current understanding of the diagnosis of mTBI and the underlying neurophysiological mechanisms of post-traumatic cognitive changes remains incomplete.This lack of clarity hinders the early diagnosis,treatment decision-making,and prognosis evaluation for mTBI.In recent years,an increasing number of multimodal magnetic resonance imaging(MRI)techniques have been applied to the diagnosis of mTBI.These include functional magnetic resonance imaging(fMRI),arterial spin labeling(ASL)perfusion imaging,susceptibility-weighted imaging(SWI),and diffusion tensor imaging(DTI).These techniques have enhanced our understanding of the neuropathological mechanisms of mTBI from different perspectives.This article reviews the application progress of the above-mentioned multimodal MRI techniques in mTBI and evaluates their advantages and disadvantages,providing new ideas for future research.
作者
吕子寒
崔杰
钟业鸣
车子刚
LÜZihan;CUI Jie;ZHONG Yeming;CHE Zigang(Department of Medical Imaging,Nanjing Tongren Hospital,School of Medicine,Southeast University,Nanjing 211102,China)
出处
《磁共振成像》
北大核心
2025年第7期129-134,共6页
Chinese Journal of Magnetic Resonance Imaging
基金
南京市卫生科技发展专项资金项目(编号:YKK23263)。
关键词
轻度创伤性脑损伤
功能磁共振成像
动脉自旋标记示踪法灌注成像
磁敏感加权成像
扩散张量成像
mild traumatic brain injury
functional magnetic resonance imaging
arterial spin labeling perfusion imaging
susceptibility-weighted imaging
diffusion tensor imaging
