摘要
帕金森病(Parkinson's disease,PD)是第二大神经退行性疾病,以静止性震颤、运动迟缓、强直和姿势不稳为典型特征。震颤为主型(tremor-dominant,TD)是PD的一种亚型,以肢体震颤为主要表现,晚期TD-PD患者的震颤症状会严重影响患者生活质量。目前磁共振成像技术的发展为TD-PD患者的脑结构形态及脑功能研究提供了许多非侵入性科学方法。因此,本文从脑结构和功能成像方面进行讨论,就三维T1加权成像(three dimensions T1-weighted imaging,3D-T1WI)、扩散张量成像(diffusiontensorimaging,DTI)、血氧水平依赖(bloodoxygenationleveldependent,BOLD)成像、磁敏感加权成像(susceptibility-weighted imaging,SWI)、磁共振波谱(magnetic resonance spectroscopy,MRS)成像、神经黑色素敏感磁共振成像(neuromelanin-sensitive MRI,NM-MRI)等多模态磁共振成像在TD-PD患者中的研究进展予以综述,为将来的研究提供新的思路。
Parkinson's disease(PD)is the second most prevalent neurodegenerative disorder,typified by resting tremors,bradykinesia,rigidity,and postural instability.The tremor-dominant(TD)subtype of PD is characterized mainly by limb tremors,which severely impact the quality of life in advanced TD-PD patients.Advances in magnetic resonance imaging(MRI)techniques have provided several non-invasive scientific methods for studying brain structure and function in TD-PD.This paper discusses the structural and functional aspects of the brain,reviewing the progress in multimodal MRI techniques such as three-dimensional T1-weighted imaging(3D-T1WI),diffusion tensor imaging(DTI),blood oxygenation level-dependent(BOLD)imaging,susceptibility-weighted imaging(SWI),magnetic resonance spectroscopy(MRS),and neuromelanin-sensitive MRI(NM-MRI)in TD-PD patients,offering new insights for future research.
作者
黄俊霖
范万峰
祖涵瑜
王玉堂
姜兴岳
HUANG Junlin;FAN Wanfeng;ZU Hanyu;WANG Yutang;JIANG Xingyue(Department of Radiology,Binzhou Medical University Hospital,Binzhou 256600,China;School of Medical Imaging,Binzhou Medical University,Yantai 264003,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2024年第12期181-186,共6页
Chinese Journal of Magnetic Resonance Imaging
基金
山东省自然科学基金项目(编号:ZR2023MH033)。
关键词
帕金森病
震颤
磁共振成像
结构磁共振成像
功能磁共振成像
Parkinson's disease
tremor
magnetic resonance imaging
structural magnetic resonance imaging
functional magnetic resonance imaging
