摘要
目的:探讨育龄期女性双相障碍躁狂发作患者治疗前后性激素水平的变化,并分析其与攻击风险的相关性。方法:观察组纳入于2018年12月-2020年8月在某医院接受治疗且符合ICD-10躁狂发作诊断标准的58例育龄期双相障碍(BD)女性患者,对照组纳入同期进行体检的58例健康育龄期女性志愿者。观察组患者均接受丙戊酸镁联合喹硫平治疗方案,并记录疗效。比较两组血清性激素水平,并分析观察组治疗8周后血清性激素水平与攻击行为相关性。结果:观察组基线期血清Prol、Testo水平高于对照组(P<0.05)。Pearson相关分析显示,基线期,血清Testo水平与财产攻击行为呈正相关(r=0.411,P<0.01);治疗8周后较基线期的变化值,血清Prol水平与言语攻击、财产攻击、MOAS总分均呈正相关(r=0.260,0.264;P<0.05),血清Testo水平与财产攻击、自身攻击、MOAS总分均呈正相关(r=0.280,0.313,0.257;P<0.05)。结论:育龄期女性双相障碍躁狂发作患者血清Prol、Testo水平存在异常;并且随着治疗的进行,患者的血清水平明显下降,攻击性也随之降低。
Objective:To investigate changes in serum sex hormone levels before and after treatment in women of reproductive age with bipolar disorder(BD)during manic episodes,and to analyze their correlation with aggressive behaviors.Methods:The observation group included 58 BD patients who met the ICD-10 diagnostic criteria for manic episodes and were treated at Zhengzhou Eighth People's Hospital between December 2018 and August 2020.The control group consisted of 58 healthy women of reproductive age who underwent physical examinations during the same period.Patients in the observation group received a combined treatment of magnesium valproate and quetiapine,and therapeutic efficacy was recorded.Serum sex hormone levels were compared between the two groups,and the correlation between serum sex hormone levels and aggressive behaviors in the observation group after 8 weeks of treatment was analyzed.Results:At baseline,serum prolactin(Prol)and testosterone(Testo)levels showed significantly elevated levels compared to the control group(P<0.05).At baseline assessment,Pearson's r demonstrated a statistically significant positive correlation between circulating testosterone levels andproperty-directed aggressive behaviors.(r=0.411,P<0.01).After 8 weeks of treatment,changes in serum Prol levels from baseline were positively correlated with verbal aggression,property aggression,and the total Modified Overt Aggression Scale(MOAS)score(r=0.260,0.264,P<0.05).Consistent with these findings,the variation in serum testosterone concentrations showed positive associations with property aggression,self-directed aggression,and overall MOAS scores.(r=0.280,0.313,0.257,P<0.05).Conclusion:Women of reproductive age with BD during manic episodes exhibit abnormal serum Prol and Testo levels;and as the treatment progresses,these patients'serum level decreaseds significantly,and their aggressiveness also decreases.
作者
宋延艳
邵玉单
刘建民
王淑贤
亓晶颖
赵小会
侯瑞
付慧鹏
李峥
李猛
SONG Yanyan;SHAO Yudan;LIU Jianmin;WANG Shuxian;QI Jingying;ZHAO Xiaohui;HOU Rui;FU Huipeng;LI Zheng;LI Meng(Zhengzhou Eighth People's Hospital/Zhengzhou MentalHeathCental,Zhengzhou 450013,China)
出处
《中国健康心理学杂志》
2025年第8期1159-1163,共5页
China Journal of Health Psychology
基金
河南省医学科技攻关计划(联合共建)项目(编号:2018020866)。
关键词
双相障碍
育龄期
喹硫平
丙戊酸镁
性激素
女性
攻击行为
Bipolar disorder
Reproductive age
Quetiapine
Magnesium valproate
Sex hormones
Women
Aggressive behavior
