摘要
目的分析改良电休克联合草酸艾司西酞普兰片治疗双相情感障碍抑郁发作患者的临床疗效。方法选取2020-10—2022-12广西壮族自治区脑科医院收治的74例双相情感障碍抑郁发作患者为对象,采用随机数字表法分为观察组(37例)与对照组(37例),对照组患者口服富马酸喹硫平片治疗,观察组患者在此基础上联合草酸艾司西酞普兰片及改良电休克治疗。2组患者均治疗4周,比较2组患者的临床疗效、精神症状、抑郁程度、认知功能、神经递质功率及不良反应发生情况。结果观察组患者总有效率91.89%,高于对照组的72.97%(P<0.05);治疗后PANSS评分[(34.96±5.23)分]、HAMD-17评分[(13.47±2.29)分]、TMT[(131.42±8.97)s]均低于对照组[分别为(38.42±5.58)分、(15.51±2.44)分、(148.96±10.81)s],脑电超慢涨落图分析仪(EFG)检测神经递质功率多巴胺[(14.96±1.39)Hz]、5-HT[(51.50±4.92)Hz]均高于对照组[分别为(13.79±1.15)Hz、(45.04±4.20)Hz],差异均有统计学意义(P<0.05)。观察组与对照组患者的总不良反应发生率分别为29.73%、43.24%,二者比较差异无统计学意义(P>0.05)。结论改良电休克联合草酸艾司西酞普兰片治疗双相情感障碍抑郁发作,能够较好缓解患者精神症状、抑郁程度,改善认知功能,调节神经递质功率,安全性较高。
Objective To analyze the clinical efficacy of modified electroconvulsive therapy and escitalopram oxalate tablets in the treatment of patients with depressive episodes of bipolar disorder.Methods From October 2020 to December 2022,74 cases of bipolar disorder depression admitted to the Guangxi Zhuang Autonomous Region Brain Hospital were selected as the study objects.The patients was divided into observation group(37 cases)and control group(37 cases)by random number method.The control group was treated with oral quetiapine fumarate tablets,and the observation group was treated with escitalopram oxalate tablets and modified electroconvulsive therapy.Both groups were treated for 4 weeks,and the clinical efficacy,psychiatric symptoms,depression degree,cognitive function,neurotransmitter levels,and adverse effects were compared.Results The overall response rate of the patients in the observation group was 91.89%,which was higher than 72.97%of the control group(P<0.05).After treatment,PANSS score((34.96±5.23)points),HAMD-17 score((13.47±2.29)points),and TMT((131.42±8.97)s)in the observation group were lower than the control group ((38.42 ± 5.58)points, (15.51 ± 2.44) points, (148.96 ± 10.81) s, respectively), the neurotransmitter power ofdopamine((14.96±1.39)Hz)and 5-HT((51.50±4.92)Hz)measured by EFG were higher than those in controlgroup((13.79±1.15)Hz and(45.04±4.20)Hz, respectively), and the differences were statistically significant(P<0.05). The incidence of total adverse reactions in the observation group and control group was 29.73% and43.24%, respectively, and the difference was not significant(P>0.05). Conclusion The combination of modifiedelectroconvulsive therapy with escitalopram tablets can relieve mental symptoms, depression degree, improvecognitive function, regulate neurotransmitter level, and have high safety.
作者
兰寒菊
韦玉辉
杨照奎
LAN Hanju;WEI Yuhui;YANG Zhaokui(Guangxi Zhuang Autonomous Region Brain Hospital,Liuzhou 545005,China)
出处
《中国实用神经疾病杂志》
2023年第12期1548-1553,共6页
Chinese Journal of Practical Nervous Diseases
基金
广西壮族自治区卫生健康委员会自筹经费科研课题(编号:Z20190277)。
关键词
双相情感障碍
抑郁发作
精神症状
改良电休克疗法
草酸艾司西酞普兰片
Bipolar disorder
Depressive episodes
Psychiatric symptoms
Modified electroconvulsive therapy
Escitalopram oxalate tablets
