摘要
目的通过孟德尔随机化(MR)方法研究特定口腔微生物与消化性溃疡(PUD)之间的潜在因果关系。方法使用东亚人群的全基因组关联研究(GWAS)数据,进行双样本MR分析,以确定口腔微生物与PUD之间的因果关系。MR分析主要通过反向方差加权法(IVW),并辅以MR-Egger和加权中值法,并对其异质性和多效性进行评估。此外,采用留一法评估MR结果的稳定性。结果特定口腔微生物属与PUD之间存在复杂关联。普雷沃氏菌可能促进十二指肠溃疡的发生,同时对胃溃疡具有保护作用。弯曲杆菌和链球菌则对胃和十二指肠溃疡表现出不同的影响。此外,梭杆菌和嗜血杆菌_A与PUD呈正相关,提示增加胃十二指肠溃疡发生的风险。结论本研究探讨了口腔微生物群与PUD之间的因果关系,为由口腔微生物介导的PUD的预防和治疗提供了新的见解。
Objective To investigate the potential causal relationship between specific oral microbiota and peptic ulcer disease(PUD)using a Mendelian randomization(MR)approach.Methods The genome-wide association study(GWAS)data from East Asian populations was utilized to perform a two-sample MR analysis to determine the causal relationship between oral microbiota and PUD.The MR analysis was primarily conducted using the inverse-variance weighted(IVW)method,supplemented by MR-Egger and weighted median methods.Heterogeneity and pleiotropy were assessed,and the leave-one-out method was employed to evaluate the stability of the MR results.ResultsThere was a complex association between specific bacterial genera of the oral microbiota and PUD.Prevotella was found to potentially promote duodenal ulcers while exerting a protective effect against gastric ulcers.Campylobacter and Streptococcus demonstrated differing effects on gastric and duodenal ulcers.Furthermore,Fusobacterium and Haemophilus_A were positively associated with peptic ulcers,suggesting an increased risk of gastroduodenal ulcer development.Conclusion This study explores the causal relationship between oral microbiota and PUD,providing new insights into the prevention and treatment of PUD mediated by oral microbiota.
作者
毛宁锋
何嘉伟
张洋
余霖
周姝含
吕文亮
MAO Ningfeng;HE Jiawei;ZHANG Yang;YU Lin;ZHOU Shuhan;LYU Wenliang(College of Traditional Chinese Medicine Clinical Medicine,Hubei University of Chinese Medicine,Wuhan 430061,P.R.China;Institute of Epidemic Disease,Hubei University of Chinese Medicine,Wuhan 430061,P.R.China;Hubei Shizhen Laboratory,Wuhan 430061,P.R.China)
出处
《中国循证医学杂志》
北大核心
2025年第7期796-802,共7页
Chinese Journal of Evidence-based Medicine
基金
国家中医药管理局中医药创新团队及人才支持计划项目(编号:ZYYCXTD-D-202203)
湖北省自然科学基金项目(编号:2023AFD138)
湖北省科学技术厅重点研发计划项目(编号:2020BCB015)
湖北中医药大学“双一流”建设重点专项科研项目(编号:2023ZZXJB003)。
