摘要
口腔微生物组在人类健康和疾病状态中发挥着重要作用。近年来癌症患者体内复杂的微生物群落特征,微生物和癌症之间的相互作用以及微生物参与癌症发生、预防和治疗的可能机制等引起了广泛关注。大量研究结果表明,微生物菌群失调通过多种途径导致癌症易感性。因此,本文主要通过回顾口腔微生物群对消化系统癌症(包括食管癌、胃癌、胰腺癌和结肠直肠癌)的影响,为口腔菌群与消化系统癌症关系的进一步研究以及口腔微生物与全身系统疾病的进一步探索提供参考。
The human oral microbiota plays an important role in both human health and disease states.Over the past decade,the interaction between microbes and cancer has attracted much attention in understanding the various characteristics of complex microbial communities and the possible mechanisms by which microbiota participates in cancer prevention,carcinogenesis,and anticancer therapy.Numerous studies have shown that microbial disorders lead to cancer susceptibility through a variety of pathways.In this article,the effects of oral microbiota on digestive system cancers(including esophageal cancer,gastric cancer pancreatic cancer,and colorectal cancer)are reviewed to provide references for further research on the relationship between oral microbiota and digestive system cancers,as well as oral microbiota and systemic diseases and cancers.
作者
张志民
程博群
ZHANG Zhimin;CHENG Boqun(Department of Endodontics, Hospital of Stomatology, Jilin University, Changchun 130021, China.)
出处
《口腔医学研究》
CAS
北大核心
2020年第2期93-97,共5页
Journal of Oral Science Research
关键词
口腔微生物组
消化系统癌症
食管癌
胃癌
胰腺癌
结直肠癌
oral microbiota
digestive system cancers
esophageal cancer
gastric cancer
pancreatic cancer
colorectal cancer
