摘要
目的:观察养心舒脉颗粒治疗老年不稳定型心绞痛(UA)瘀热相搏型的临床疗效。方法:选取60例老年UA病人,随机分为观察组和对照组,各30例。对照组给予常规治疗,观察组在对照组基础上加用养心舒脉颗粒,每次20 g,每日3次,两组连续治疗12周。比较两组中医证候积分、心绞痛发作情况、心电图疗效、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)变化。结果:治疗后,观察组中医证候积分、发作频率、持续时间、硝酸甘油用量、TC、LDL-C、TNF-α、IL-6较治疗前减少,SAQ积分较治疗前增高,且观察组优于对照组,差异均有统计学意义(P<0.05)。观察组心电图总有效率高于对照组,差异有统计学意义(76.67%与46.67%,P<0.05)。结论:养心舒脉颗粒治疗老年UA瘀热相搏型,可改善病人心绞痛发作情况,提高临床疗效,其机制与降血脂、抗炎作用有关。
Objective:To explore the clinical effect of Yangxin Shumai Granules for the treatment of unstable angina pectoris(UA)in the elderly with contention between static and heat.Methods:Sixty elderly patients with UA were randomly divided into the observation group and the control group,with 30 cases in each group.The patients of the control group were treated with conventional treatment,while the patients of the observation group were supplemented with Yangxin Shumai Granules on the basis of the control group,20 g each time,three times a day.Both groups were treated continuously for 12 weeks.The traditional Chinese medicine syndrome scores,angina pectoris attack conditions,electrocardiogram therapeutic effects,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)were compared between two groups.Results:After treatment,compared with data before treatment,the traditional Chinese medicine syndrome scores,attack frequency,duration,nitroglycerin dosage,TC,LDL-C,TNF-α,and IL-6 in the observation group decreased,the SAQ score increased,while the results of observation group were superior to those of the control group.There were statistically significant differences(76.67%vs 46.67%,P<0.05).The total effective rate of electrocardiogram in the observation group was higher than that in the control group,and there were statistically significant differences(P<0.05).Conclusion:Yangxin Shumai granules for the treatment of UA in the elderly with contention between static and heat could improve attack of angina pectoris,enhance clinical effect.The mechanism was related to lowering blood lipid and inhibiting inflammation.
作者
徐奚如
潘明垚
方媛
王晗
XU Xiru;PAN Mingyao;FANG Yuan;WANG Han(Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,Jiangsu,China)
出处
《中西医结合心脑血管病杂志》
2025年第14期2092-2095,共4页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
江苏省干部保健科研项目(No.BJ20021)
江苏省卫健委老年健康科研项目(No.LKZ2023002)
第七批全国老中医药专家学术经验继承工作,编号:国中医药人教函〔2022〕76号。
关键词
不稳定型心绞痛
瘀热相搏型
养心舒脉颗粒
血脂
炎性因子
unstable angina pectoris
contention between static and heat
Yangxin Shumai Granules
blood lipid
inflammatory factors
