摘要
目的 探讨布地奈德福莫特罗粉吸入剂对慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease,COPD)急性发作期患者氧化应激反应和胸肺顺应性的影响。方法 采用抽签法将2022年10月至2024年10月在鹤壁煤业(集团)有限责任公司总医院接受诊治的110例COPD急性发作期患者平均分为2组,常规组55例接受噻托溴铵粉吸入及无创机械通气等常规治疗,研究组55例在常规组的基础上给予布地奈德福莫特罗粉吸入剂治疗,比较两组治疗前、治疗1周后胸肺顺应性、呼吸动力学,治疗2周后肺功能及血清氧化应激分子水平和不良反应。结果 治疗1周后,研究组胸廓顺应性(Chest Wall Compliance,CTh)、肺顺应性(Lung Compliance,CI)、总顺应性(Total Compliance,Ct)和吸气峰值压(Peak Airway Pressure,PIP)高于常规组,气道阻力(Airway Resistance,Raw)、平均气道压(Mean Airway Pressure,MPaw)低于常规组(P <0.05)。治疗2周后,研究组用力肺活量(Forced Vital Capacity,FVC)、第1秒用力呼气容积(Forced Expiratory Volume in the First Second,FEV1)、超氧化物歧化酶(Superoxide Dismutase,SOD)、过氧化氢酶(Catalase,CAT)和FEV1/FVC高于常规组,丙二醛低于常规组(P <0.05),两组不良反应无显著差异(P> 0.05)。结论 对COPD急性发作期患者,在常规治疗的基础上给予布地奈德福莫特罗粉吸入剂治疗,可快速有效且安全地改善其呼吸动力学和胸肺顺应性,并促进其氧化应激反应和肺功能的改善。
Objective To investigate the effects of budesonide formoterol powder inhalation on oxidative stress and thoracic lung compliance in patients with the acute attack stage of chronic obstructive pulmonary disease(COPD).Methods A total of 110 patients with the acute attack stage of COPD in General Hospital of Hebi Coal Industry Group Co.,Ltd.from October 2022 to October 2024 were divided into 2 groups.In the conventional group,55 patients received tiotropium bromide powder inhalation and non-invasive mechanical ventilation and other conventional treatments.In the study group,55 patients were treated with budesonide formoterol powder inhalation on the basis of the conventional group.The thoracic lung compliance,respiratory dynamics,pulmonary function and serum oxidative stress molecular level and adverse reactions between the two groups were compared before and after 1 week of treatment.Results Chest wall compliance(CTh),lung compliance(CI),total compliance(Ct)and peak airway pressure(PIP)after 1 week in the study group were higher than those of the conventional group,and the airway resistance(Raw)and mean airway pressure(MPaw)were lower than those of the conventional group(P<0.05).After 2 weeks of treatment,forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),superoxide dismutase(SOD),catalase(CAT)and FEV1/FVC in the study group were higher than those of the conventional group,and malondialdehyde was lower than that of the conventional group(P<0.05).There was no significant difference in total adverse reactions between the two groups(P>0.05).Conclusion Budesonide formoterol powder inhalation can improve the respiratory dynamics and thoracic lung compliance of patients with the acute attack stage of COPD,and promote the improvement of oxidative stress and pulmonary function.
作者
董利娜
谷凡
徐强
DONG Lina;GU Fan;XU Qiang(Department of Pharmaceutical Equipment,General Hospital of Hebi Coal Industry Group Co.,Ltd.,Hebi,Henan 458000,China;Department of Cardiothoracic Oncology,General Hospital of Hebi Coal Industry Group Co.,Ltd.,Hebi,Henan 458000,China;Department of Respiratory and Critical Care Medicine,General Hospital of Hebi Coal Industry Group Co.,Ltd.,Hebi,Henan 458000,China)
出处
《生物医学工程学进展》
2025年第3期304-310,共7页
Progress in Biomedical Engineering
关键词
布地奈德福莫特罗粉
慢性阻塞性肺疾病
急性发作
氧化应激
胸肺顺应性
Budesonide Formoterol Powder
Chronic Obstructive Pulmonary Disease(COPD)
Acute Attack
Oxidative Stress
Thoracic Lung Compliance
