摘要
目的:分析真武汤合葶苈大枣泻肺汤联合西药治疗阳虚水泛证慢性阻塞性肺疾病(COPD)患者的效果。方法:选取2022年12月—2024年12月厦门市中医院收治的104例阳虚水泛证COPD患者,按随机数字表法分为两组,各52例。对照组行西药治疗,观察组加以真武汤合葶苈大枣泻肺汤治疗。对比两组治疗效果。结果:观察组治疗总有效率为96.15%(50/52),高于对照组的84.62%(44/52),差异有统计学意义(P<0.05)。治疗2周后,观察组咳喘倚息不能卧、咳痰质稀、胸膈憋闷、面唇紫黯、心悸、畏寒、小便量少评分分别为(1.58±0.16)、(1.44±0.17)、(1.36±0.16)、(0.71±0.10)、(0.64±0.08)、(0.63±0.05)、(0.81±0.09)分,PaCO_(2)为(41.42±3.21)mmHg,IL-6、CRP、降钙素原、TNF-α分别为(6.49±1.02)pg/mL、(8.33±1.29)mg/L、(0.12±0.01)μg/L、(4.59±0.63)μg/L,均低于对照组的(2.63±0.24)、(2.36±0.20)、(2.48±0.27)、(1.24±0.18)、(1.35±0.12)、(1.19±0.12)、(1.42±0.18)分,以及(45.35±4.69)mmHg、(8.35±1.25)pg/mL、(10.61±1.68)mg/L、(0.18±0.03)μg/L、(6.35±1.05)μg/L;PaO_(2)为(80.69±8.44)mmHg,高于对照组的(71.59±7.35)mmHg,6分钟步行试验(6MWT)距离为(435.98±48.64)m,长于对照组的(369.82±40.59)m;上述各指标比较,差异有统计学意义(P<0.05)。两组不良反应对比,差异无统计学意义(P>0.05)。结论:真武汤合葶苈大枣泻肺汤联合西药能调节阳虚水泛证COPD患者血气指标,减轻炎症,提高运动耐力,安全可行。
Objective:To analyze the effect of Zhenwu Decoction and Tingli Dazao Xiefei Decoction combined with western medicine in the treatment of chronic obstructive pulmonary disease(COPD)patients with Yang deficiency and water flooding syndrome.Method:A total of 104 COPD patients with Yang deficiency and water flooding syndrome were admitted to Xiamen Hospital of T.C.M from December 2022 to December 2024.They were randomly divided into two groups,with 52 patients in each group,using a random number table method.The control group was treated with western medicine,while the observation group was additionally treated with Zhenwu Decoction and Tingli Dazao Xiefei Decoction.The therapeutic effects of two groups were compared.Result:The total effective rate of the observation group was 96.15%(50/52),which was higher than the control group's 84.62%(44/52),the difference was statistically significant(P<0.05).After 2 weeks of treatment,the cough wheezing inability to lie down,sparse sputum,chest and diaphragm tightness,dark purple on the face and lips,palpitations,chills,and reduced urine output scores of the observation group were(1.58±0.16),(1.44±0.17),(1.36±0.16),(0.71±0.10),(0.64±0.08),(0.63±0.05),(0.81±0.09)points,respectively,PaCO_(2) was(41.42±3.21)mmHg,and the IL-6,CRP,procalcitonin,and TNF-α were(6.49±1.02)pg/mL,(8.33±1.29)mg/L,(0.12±0.01)μg/L,and(4.59±0.63)μg/L,which were all lower than the control group's(2.63±0.24),(2.36±0.20),(2.48±0.27),(1.24±0.18),(1.35±0.12),(1.19±0.12),(1.42±0.18)points,and(45.35±4.69)mmHg,(8.35±1.25)pg/mL,(10.61±1.68)mg/L,(0.18±0.03)μg/L,and(6.35±1.05)μg/L,respectively;the PaO_(2) was(80.69±8.44)mmHg,higher than the control group's(71.59±7.35)mmHg;the 6-minute walking test(6MWT)distance was(435.98±48.64)m,longer than the control group's(369.82±40.59)m;there were statistically significant differences in the above indicators(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Zhenwu Decoction and Tingli Dazao Xiefei Decoction combined with western medicine can regulate blood gas indicators,reduce inflammation,improve exercise endurance,and is safe and feasible for COPD patients with Yang deficiency and water flooding syndrome.
作者
王秋林
WANG Qiulin(Department of Respiratory and Critical Care Medicine,Xiamen Hospital of T.C.M,Xiamen 361000,China)
出处
《中国医学创新》
2025年第20期24-28,共5页
Medical Innovation of China
关键词
慢性阻塞性肺疾病
真武汤合葶苈大枣泻肺汤
阳虚水泛
血气指标
运动耐力
不良
反应
Chronic obstructive pulmonary disease
Zhenwu Decoction and Tingli Dazao Xiefei Decoction
Yang deficiency and water flooding
Blood gas indicators
Exercise endurance
Adverse reactions
