摘要
目的 探讨西洋参联合苯磺酸氨氯地平片对老年原发性高血压患者的临床疗效。方法 选取2023年1—12月南华大学附属第二医院收治的150例老年原发性高血压患者为研究对象。按照随机数表法分为对照组(n=75,苯磺酸氨氯地平片治疗)与观察组(n=75,西洋参联合苯磺酸氨氯地平片治疗)。比较2组中医症候评分、临床疗效、血压、血液流变学指标。结果 治疗后,观察组头晕、头痛、烦躁、心悸、失眠等中医症候评分分别为(1.07±0.31)分、(0.63±0.15)分、(0.71±0.12)分、(0.88±0.23)分、(1.21±0.39)分,低于对照组的(1.79±0.62)分、(1.12±0.57)分、(0.94±0.45)分、(1.15±0.42)分、(1.66±0.36)分,差异有统计学意义(P <0.001)。观察组治疗总有效率为97.33%,高于对照组的82.67%,差异有统计学意义(P<0.05)。观察组收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)、脉压差分别为(112.32±5.01)mmHg、(83.98±5.89)mmHg、(28.51±4.22)mmHg,低于对照组的(129.47±6.13)mmHg、(87.42±3.29)mmHg、(41.42±5.19)mmHg,差异有统计学意义(P<0.001)。观察组全血高切黏度(high-shear blood viscosity,HBV)、全血低切黏度(low-shear blood viscosity,LBV)、血浆黏度(plasma viscosity,PV)和红细胞聚集指数(red cell assemblingindex,Arbc)分别为(4.22±0.69)mPa·s、(8.36±1.44)mPa·s、(1.19±0.18)mPa·s、(1.46±0.74),低于对照组的(5.01±0.93)mPa·s、(12.48±1.98)mPa·s、(1.57±0.36)mPa·s、(1.82±0.92),差异有统计学意义(P <0.05)。结论 在老年原发性高血压患者的治疗中采用西洋参联合苯磺酸氨氯地平片能有效促进患者血压的控制情况,进而提高临床疗效。
Objective To investigate the clinical effect of American ginseng combined with amlodipine besylate tablets in elderly patients with essential hypertension.Methods A total of 150 elderly patients with essential hypertension admitted to the Second Affiliated Hospital,University of South China from January to December 2023 were selected as the study objects.They were divided into the control group(n=75,amlodipine besylate tablets treatment)and the observation group(n=75,American ginseng combined with amlodipine besylate tablets treatment)according to the random number table methods.The TCM symptom score,clinical efficacy,blood pressure and hemorheology indexes were compared between the two groups.Results After treatment,the scores of TCM symptoms such as dizziness,headache,irritability,palpitation and insomnia in the observation group were(1.07±0.31)points,(0.63±0.15)points,(0.71±0.12)points,(0.88±0.23)points and(1.21±0.39)points,respectively,whichwerelowerthan(1.79±0.62)points,(1.12±0.57)points,(0.94±0.45)points,(1.15±0.42)points,(1.66±0.36)points in the control group,the differences were statistically significant(P<0.001).The total effective rate of the observation group was 97.33%,which was higher than 82.67%of the control group,and the difference was statistically significant(P<0.05).The systolic blood pressure(SBP),diastolic blood pressure(DBP)and pulse pressure difference in the observation group were(112.32±5.01)mmHg,(83.98±5.89)mmHg and(28.51±4.22)mmHg,which were lower than(129.47±6.13)mmHg,(87.42±3.29)mmHg,(41.42±5.19)mmHg in the control group,the differences were statistically significant(P<0.001).Whole blood high-shear blood viscosity(HBV),whole blood low-shear blood viscosity(LBV),plasma viscosity(PV)andred cell assembling index(Arbc)in the observation group were(4.22±0.69)mPa·s,(8.36±1.44)mPa·s,(1.19±0.18)mPa·s and(1.46±0.74),respectively,which were lower than(5.01±0.93)mPa·s,(12.48±1.98)mPa·s,(1.57±0.36)mPa·s,(1.82±0.92)in the control group,and the differences were statistically significant(P<0.05).Conclusion In the treatment of elderly patients with essential hypertension,American ginseng combined with amlodipine besylate tablets can effectively promote the control of patients'blood pressure,and then improve the clinical efficacy.
作者
钟细林
李志军
ZHONG Xilin;LI Zhijun(Department of Pharmacy,the Second Affiliated Hospital,University of South China,Hengyang Hunan 421000,China;Department of Laboratory Pathology,Lintong Rehabilitation and Convalescence Center,Xi'an Shaanxi 710000,China)
出处
《中国卫生标准管理》
2025年第8期135-138,共4页
China Health Standard Management
关键词
西洋参
苯磺酸氨氯地平片
原发性高血压病
血压
血液流变学指标
影响
American ginseng
amlodipine besylate tablets
essential hypertension
blood pressure
hemorheology index
influence
