摘要
慢性疲劳综合征(CFS)属于中医学“虚劳”范畴,脾为“气血生化之源”“后天之本”,故脾虚是CFS的关键病机。现代医学认为线粒体功能障碍是导致慢性疲劳综合征的关键因素,涉及氧化磷酸化途径受损、氧化应激激活、免疫炎症异常等多个病理机制。早在20世纪80年代就有学者提出“脾-线粒体相关”理论,二者作为人体能量枢纽,在CFS患者的发病中紧密相关,涉及骨骼肌代谢、免疫炎症反应等损害机制。健脾类中医疗法可以改善CFS患者的症状,提高其生命质量。该研究基于“脾-线粒体”相关论系统阐述从脾论治CFS的中西医理论依据,揭示CFS“脾虚”病机的科学内涵,为中医治疗CFS患者提供客观的理论支持。
Chronic fatigue syndrome(CFS) falls under the category of “consumptive disease” in traditional Chinese medicine(TCM).The spleen is regarded as the “source of qi and blood production” and the “acquired foundation”,making spleen deficiency a key pathogenesis of CFS in TCM theory.In modern medicine,mitochondrial dysfunction is considered a critical factor in the development of CFS,involving impaired oxidative phosphorylation,activated oxidative stress,and abnormal immune-inflammatory responses.As early as the 1980s,scholars proposed the “spleen-mitochondria” correlation theory,suggesting a close relationship between the two energy centers of the human body in the pathogenesis of CFS.This relationship involves damage mechanisms such as skeletal muscle metabolism disorders and immune-inflammatory responses.Spleen-strengthening TCM therapies can alleviate symptoms in CFS patients and improve their quality of life.Based on the “spleen-mitochondria” correlation theory,this study systematically elucidates the theoretical basis of treating CFS from the spleen in TCM and Western medicine,and reveals the scientific connotation of the “spleen deficiency” mechanism in CFS,providing objective theoretical support for TCM treatment of CFS.
作者
张思宁
刘溦溦
韩秀珍
马紫慧
任娜
张晓蕾
马国海
商洪涛
ZHANG Sining;LIU Weiwei;HAN Xiuzhen;MA Zihui;REN Na;ZHANG Xiaolei;MA Guohai;SHANG Hongtao(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China;Jiangsu Province Hospital of Chinese Medicine,Nanjing 210029,China;Hangzhou Lin′an Traditional Chinese Medicine Hospital,Hangzhou 311300,China)
出处
《世界中医药》
北大核心
2025年第6期1004-1010,共7页
World Chinese Medicine
基金
国家自然科学基金项目(81904122)——增液布津方通过调节肠道共生菌群激活腺苷酸受体ADOR重建机体免疫应答治疗干燥综合症的机制研究
江苏省老年医学临床技术应用研究项目(LD2021004)。
关键词
脾
线粒体
慢性疲劳综合征
免疫
炎症
氧化应激
脾为之卫
后天之本
Spleen
Mitochondria
Chronic fatigue syndrome
Immune
Inflammatory
Oxidative stress
Spleen governs the defensive function
Acquired foundation
