摘要
曾于1984年提出了中医"脾-线粒体相关"理论,认为线粒体与中医的脾有着密切的联系。此后通过对16例脾胃气虚、16例肝胃不和型胃脘痛患者及3例正常人胃黏膜进行透射电镜观察,发现:脾胃气虚胃脘痛患者壁细胞线粒体数目、主细胞单位面积内酶原颗粒计数较正常组、肝胃不和组明显减少;壁细胞及浆细胞均可见线粒体肿胀,膜缺损,嵴断裂、基质变淡等变化,与对照组相比有明显差异。认为中医脾主运化不仅仅是指食物在胃肠道的消化吸收,更重要的是在线粒体的氧化磷酸化过程。把线粒体作为"脾"的重要组成部分,不仅能较确切地解释中医脾主运化,而且能与中医的脾主肌肉、四肢,主统血,脾开窍于口,其华在唇的论点相联系,并有助于解释脾与五脏相关的学说。
The auther elucidated the TCM theory of ＂ spleen -mitochondria correlation＂ in 1984, thought that mito- chondria and spleen of TCM had close relationship. After that ,we observed gastric mucosa of 16 cases spleen - stomach qi deficiency, 16 cases liver - stomach disharmony gastric abscess patients and 3 cases health adults through transmission electron microscope ,found that mitochondria number of acid cell of spleen - stomach qi deficiency astric abscess patients, counted number of zymogen granule of adelomorphous cell in unit area obviously decreased obviously compared with control group and liver - stomach disharmony group; mitochondria swollen, membrane defected, eristae broken, matrix thinningzed in both acid cell and adelomorphous cell, which had obvious difference compared with control group. We think that spleen governing transportation and transformation is not merely gastrointestinal digestion and absorption of food, most important is the mitochondria oxidative phosphorylation. Take mitochondria as the important ingredient of spleen, not only explain precisely spleen governing transportation and transformation of TCM, but also can contact with spleen nourishing the muscles,limbs;spleen governing blood, mouth and oral lip reflecting spleen etc, also conduce to explain the theory of spleen related to five organs.
出处
《中华中医药学刊》
CAS
2007年第12期2439-2442,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(30371706)
关键词
胃脘痛
胃黏膜
脾
线粒体
gastric abscess
gastric mucosa
spleen
mitochondria
