摘要
目的探讨联合应用百令胶囊和维生素D治疗育龄期女性自身免疫性甲状腺炎的临床效果,以及对血清(OH)D和Th1/Th2相关因子的影响。方法纳入2020年1月—2022年8月在医院就诊的94例育龄期女性自身免疫性甲状腺炎患者,随机分为研究组和对照组,每组47例。对照组接受甲状腺素钠片和维生素D口服治疗,研究组在此基础上加用百令胶囊口服治疗,治疗持续6个月。测定并比较两组在不同时间点的FT3、FT4、TSH、TRAb、TPO-Ab、25(OH)D水平以及Th1/Th2相关因子。结果治疗6个月后,研究组的FT3和FT4水平略低于对照组,但差异无统计学意义(P>0.05);研究组的TSH水平明显高于对照组(P<0.05)。治疗3、6个月后,对照组患者的TRAb和TPO-Ab水平与治疗前相比无显著差异(P>0.05)。然而,研究组在治疗3个月后TRAb和TPO-Ab水平显著降低,差异具有统计学意义(P<0.05)。治疗6个月后,研究组患者的TRAb和TPO-Ab水平明显低于同组治疗前及治疗3个月后,且均低于对照组(P<0.01)。此外,研究组患者的血清25(OH)D水平在治疗6个月后明显升高,与同期对照组和治疗前相比差异均具有统计学意义(P<0.05)。治疗6个月后,研究组的INF-γmRNA和IL-10mRNA水平显著优于对照组患者,两者差异具有统计学意义(P<0.01)。结论百令胶囊联合维生素D治疗可显著改善育龄期女性自身免疫性甲状腺炎患者的血清25(OH)D水平和自身免疫抗体滴度,为低维生素D水平的自身免疫性甲状腺炎患者提供了一种有效辅助治疗方案。
Objective To explore the clinical efficacy of combined application of Bailing Capsule(百令胶囊)and vitamin D in the treatment of autoimmune thyroiditis in women of childbearing age,as well as the effects on serum 25(OH)D and Th1/Th2.Methods Ninety-four female patients with autoimmune thyroiditis of childbearing age admitted to the hospital from January 2020 to August 2022 were selected as the research subjects and randomly divided into a study group and a control group,with 47 cases in each group.The control group received thyroxine sodium tablets and vitamin D oral treatment,and the study group was combined with Bailing Capsule oral treatment on the basis of the control group.The treatment lasted for 6 months.The levels of free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH),thyroid stimulating hormone receptor antibody(TRAb),thyroid peroxidase antibody(TPO-Ab),25(OH)D and Th1/Th2 were measured and compared in two groups at different stages.Results After 6 months of treatment,the levels of FT3 and FT4 in the study group were slightly lower than those in the control group(P>0.05),and the TSH level in the study group was significantly higher than that in the control group(P<0.05).After 3 and 6 months of treatment,there was no significant difference in TRAb or TPO-Ab in the control group(P>0.05).After 3 months of treatment,the levels of TRAb and TPO-Ab in the study group were significantly lower than those before treatment(P<0.05).After 6 months of treatment,the levels of TRAb and TPO-Ab in the study group were significantly lower than those before treatment and after 3 months of treatment,and both were lower than those of the control group(P<0.01).After 6 months of treatment,the serum 25(OH)D levels in the study group were significantly higher than those before treatment and those of the control group during the same period(P<0.05).After 6 months of treatment,the levels of interferon(INF)-γmRNA and interleukin(IL)-10 mRNA in the study group were significantly higher than those in the control group,with statistically significant differences(P<0.01).Conclusion The combination of Bailing Capsule and vitamin D can significantly improve the serum 25(OH)D levels and autoimmune antibody titers in women with autoimmune thyroiditis of childbearing age,providing an effective adjuvant therapy for autoimmune thyroiditis patients with low vitamin D levels.
作者
王宗攀
王文栋
王阳晴
周少芳
WANG Zongpan;WANG Wendong;WANG Yangqing;ZHOU Shaofang(Quzhou Hospital Affiliated to Wenzhou Medical University,Quzhou People's Hospital,Quzhou 324000,Zhejiang,China)
出处
《中华中医药学刊》
北大核心
2025年第6期213-216,共4页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省中医药科技计划项目(2019ZB109)。
