摘要
目的 评估辅助生殖技术中多囊卵巢综合征(PCOS)患者血清中维生素D水平及其与胚胎质量和妊娠率之间的关系.方法 本研究共纳入了辅助生殖助孕治疗中的32例PCOS患者和因输卵管因素导致不孕的28例对照.检测血清中25羟基维生素D水平,记录体重指数、获卵数、受精率、优胚率和妊娠率用于分析.结果 两组均有较高的维生素D缺乏率.与对照组比较,血清维生素D水平在PCOS组(P =0.041)显著降低.但两组间优胚率和妊娠率比较,差异均无统计学意义.维生素D缺乏与否与上述指标也没有相关性.结论 维生素D缺乏在不孕症人群中普遍存在,PCOS妇女尤甚.但是尚未发现维生素D缺乏与胚胎质量与妊娠率之间的关系,仍需要开展大样本数据深入研究探讨.
Objective To assess the serum vitamin D level in polycystic ovary syndrome(PCOS) referred for assisted reproductive technology(ART) and relationship between the serum vitamin D status and the quality of the embryos and pregnant rate in these women. Methods Thirty-two women with PCOS and 28 control women with tubal infertility referred for ART were recruited. Serum levels of 25(OH) vitamin D was measured. The body mass index, fertilization rate, high-quality embryo rate, biochemical pregnant rate and clinical pregnant rate were documented for analysis. Results The incidence of vitamin D deficiency were both high in these two groups. When compared with control, the serum vitamin D level was significantly decreased in PCOS group(P=0.041). There was no significant difference in high-quality embryo rate and pregnant rate between the two groups. Vitamin D deficiency had no relation with the high-quality embryo rate and pregnant rate. Conclusion Vitamin D deficiency is common in the population of IVF, especially in those PCOS women. However, the effects of vitamin D on the quality of the embryos and pregnant rate are not found. Appropriately designed studies are needed to better explore the influence of vitamin D in PCOS and ART patients.
作者
桂娟
张婕
徐望明
谢青贞
夏旖
Gui Juan;Zhang Jie;Xu Wangming(Renmin Hospital of Wuhan University,Hubei 430060,China)
出处
《医学研究杂志》
2020年第3期52-55,共4页
Journal of Medical Research
基金
国家自然科学基金青年科学基金资助项目(81601248)。
关键词
维生素D
多囊卵巢综合征
辅助生殖技术
Vitamin D
Polycystic ovary syndrome
Assisted reproductive technology
