摘要
川崎病是一种急性自限性血管炎,主要好发于5岁以下儿童,是儿童后天性心脏病的首位病因,冠状动脉病变是其最主要的并发症。其诊断主要依靠临床症状而缺乏特异性的实验室检测指标。该文将从基因组学、转录组学、蛋白质组学三个层面对有关川崎病诊断的敏感生物标志物研究进展进行综述。
Kawasaki disease is an acute self-limiting vasculitis,mainly occurs in children under 5 years old.It is the first cause of acquired heart disease in children.The main complication is coronary artery disease.Till now the diagnosis is based mainly on the clinical symptoms for the lack of diagnostic laboratory tests.This article will review the sensitive biomarkers of Kawasaki disease from the three aspects of genomics,transcriptomics and proteomics study.
作者
左梦颖
吕海涛
ZUO Meng-ying;LV Hai-tao(Department of Cardiology,Children's Hospital of Soochow University,Suzhou,Jiangsu,215025,China)
出处
《中国血液流变学杂志》
2024年第4期666-670,共5页
Chinese Journal of Hemorheology
基金
国家自然科学基金资助项目(82270529)
2024年度医院疑难病、罕见病研究专项项目(2024YNHJ13)。
关键词
川崎病
生物标志物
诊断
Kawasaki disease
biomarker
diagnosis
