摘要
目的分析糖皮质激素联合双嘧达莫治疗川崎病患儿的效果及对现相关指标水平的影响。方法选取2018年3月—2020年12月在湖州市第一人民医院就诊的86例川崎病患儿,依据治疗方式分为研究组和对照组,每组各43例患儿。所有患儿给予常规对症治疗,对照组给予口服双嘧达莫,研究组给予糖皮质激素+双嘧达莫治疗,两组患儿均治疗14 d。比较两组患儿治疗前后的红细胞沉降率(ESR)、成纤维细胞生长因子23(FGF23)、趋化素水平及炎症细胞因子、凝血指标,临床症状消失时间,冠脉病变发生率及治疗有效率。结果治疗后,研究组ESR、FGF23、趋化素、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)、凝血酶时间(TT)、凝血酶原时间(PT)、纤维蛋白原(Fbg)水平均低于对照组(均P<0.05)。研究组患儿发热、黏膜弥漫性充血、躯干红斑、淋巴结肿胀、结膜充血临床症状消失时间均短于对照组(均P<0.05)。研究组患儿冠状动脉损害发生率(18.60%)低于对照组(55.81%),差异有统计学意义(χ^(2)=12.741,P<0.05)。研究组治疗总有效率(95.35%)明显高于对照组(67.44%),差异有统计学意义(χ^(2)=11.057,P<0.05)。结论采用糖皮质激素联合双嘧达莫对川崎病患儿进行治疗,可有效改善患儿ESR、FGF23、趋化素、凝血指标水平及临床症状,缓解炎症反应,降低冠脉病变发生率,效果较好。
Objective To analyze the effect of glucocorticoid combined with dipyridamole in treatment of children with Kawasaki disease and the impact on levels of related indexes.MethodsA total of 86 children with Kawasaki disease treated in the First People's Hospital of Huzhou City from March 2018 to December 2020 were selected and divided into study group and control group according to treatment method,43 children in each group.All the children were treated with routine therapy,the children in control group were treated with oral administration of dipyrimidole,and the children in study group were treated with glucocorticoid combined with dipyridamole,the children in the two groups were treated for 14 days.The levels of erythrocyte sedimentation rate(ESR),fibroblast growth factor 23(FGF23),chemerin,inflammatory factors,and coagulation indicators before and after treatment,disappearance time of clinical symptoms,incidence rates of coronary lesions,and effective rates of treatment in the two groups were compared,Results After treatment,the levels:of ESR,FGF23,chemerin,interleukin-1(IL-1),interleukin-6(IL-6),C-reactive protein(CRP),thrombin time(TT),prothrombin time(PT),and fibrinogen in study group were statistically significantly lower than those in control group(P<0.05).The disappearance time of fever,diffuse mucosal congestion,trunk erythema,lymph node swelling,and conjunctival congestion in study group was shorter than that in control group(P<0.05).The incidence rate of coronary artery damage in study group was 18.60%,which was statistically significantly lower than that in control group(55.81%)(χ^(2)=12.741,P<0.05).The total effective rate in study group was 95.35%,which was statistically significantly higher than that in control group(67.44%)(χ^(2)=11.057,P<0.05).Conclusion The treatment of Kawasaki disease children with glucocorticoid and dipyridamole can efectively improve ESR,FGF23,chemerin,coagulation indicators levels and clinical symptoms,relieve inflammatory response,reduce the incidence rate of coronary lesions,the curative effect is good.
作者
潘佳惠
袁琛
郎妍
汪岭
PAN Jia-hui;YUAN Chen;LANG Yan;WANG Ling(Department of Pediatrics,the First People's Hospital of Huzhou City,Huzhou,Zhejiang 313000,China)
出处
《中国妇幼保健》
CAS
2023年第19期3681-3685,共5页
Maternal and Child Health Care of China
基金
浙江省医药卫生科技计划项目(2019KY209)
浙江省湖州市科学技术局项目(2017GYB52)。
