摘要
目的探讨婴儿川崎病冠状动脉病变的临床特点及危险因素。方法选择2018年1月至2023年1月中国科学技术大学附属第一医院(安徽省立医院)收治的婴儿川崎病患者150例,根据患者是否合并冠状动脉病变分为病例组37例、对照组113例,比较两组临床资料,采用多因素Logistic分析婴儿川崎病冠状动脉病变的危险因素,分析血清红细胞沉降率(ESR)、血小板计数(PLT)对婴儿川崎病冠状动脉病变的诊断效能。结果两组年龄、WBC、PDW、RBC、HGB、MPV、NLR、PCT及CK⁃MB比较差异无统计学意义(P>0.05);两组性别、CRP、ALB、RDW、ESR及PLT比较差异有统计学意义(P<0.05);多因素Logistic回归分析显示,性别男、CRP升高、ALB降低、RDW升高、ESR升高及PLT升高均是导致婴儿川崎病冠状动脉病变的危险因素(P<0.05);ROC结果显示,血清ESR预测婴儿川崎病冠状动脉病变的AUC为0.872,灵敏度为0.867,特异度为0.882,PLT预测婴儿川崎病冠状动脉病变AUC为0.892,灵敏度为0.887,特异度为0.893。结论婴儿川崎病冠状动脉病变患者的临床特点及危险因素较多,检测血清ESR、PLT有较高的预测价值,临床上应予以密切关注以降低冠状动脉病变的发生率。
Objective To study clinical characteristics and risk factors of coronary artery disease in infants with Kawasaki disease.Methods 150 cases of infant Kawasaki disease were admitted to Anhui Provin⁃cial Hospital from January 2018 to January 2023.They were selected and divided into two groups:a case group(37 cases)and a control group(113 cases)based on whether the patients were complicated with coronary artery disease.The clinical data of both groups were compared,and the risk factors for coronary artery disease in infant Kawasaki disease were analyzed using multivariate logistic analysis.A receiver operating characteristic curve(ROC)was used to analyze the diagnostic efficacy of serum ESR and PLT for coronary artery disease in infants with Kawasaki disease.Results There were no significant differences in age,WBC,PDW,RBC,HGB,MPV,NLR,PCT,and CK⁃MB between the two groups(P>0.05).However,there were significant differ⁃ences in gender,CRP,ALB,RDW,ESR,and PLT between the two groups(P<0.05).Multivariate logistic re⁃gression analysis showed that gender,elevated CRP,decreased ALB,elevated RDW,elevated ESR,and el⁃evated PLT were all risk factors for coronary artery disease in infants with Kawasaki disease(P<0.05).The ROC results indicated that serum ESR predicted the AUC of infant Kawasaki disease with 0.872,sensitivity of 0.867,and specificity of 0.882.PLT count predicted the AUC of infant Kawasaki disease with 0.892,sensitivity of 0.887,and specificity of 0.893.Conclusion There are many risk factors for patients with coronary artery disease during Kawasaki disease in infants.The detection of serum ESR and PLT level has a high predictive value,and it should be closely monitored in in clinic settings to reduce the incidence of coronary artery disease.
作者
刘威
张兰
LIU Wei;ZHANG Lan(Department of Pediatrics,Anhui Provincial Hospital,Hefei,Anhui,China 230001)
出处
《分子诊断与治疗杂志》
2025年第1期38-40,45,共4页
Journal of Molecular Diagnostics and Therapy
基金
安徽省高等学校省级质量工程项目(2021jyxm1760)。
关键词
婴儿
川崎病
冠状动脉病变
红细胞沉降率
血小板计数
Babies
Kawasaki disease
Coronary artery disease
Erythrocyte sedimentation rate
Platelet count
