摘要
目的:探讨高频超声弹性成像参数联合血清抗甲状腺球蛋白抗体(TgAb)、可溶性白介素-2受体(sIL-2R)水平检测对甲状腺结节性质的鉴别诊断价值。方法:回顾性分析2021年6月至2023年6月我院收治的83例甲状腺结节患者的临床资料,均行高频超声弹性成像检查,根据细针穿刺或术后病理结果,将患者分别纳入良性组(52例)与恶性组(31例)。比较2组影像学特征、高频超声弹性成像参数(弹性应变率、弹性评分)及血清TgAb、sIL-2R水平,分析联合应用对甲状腺恶性结节的诊断价值。结果:恶性组回声不均匀、形态不规则、伴穿支血管、边界不清晰及砂砾样钙化占比高于良性组(P<0.01);恶性组高频超声弹性成像参数弹性应变率、弹性评分及血清TgAb、sIL-2R水平均高于良性组(P<0.01);高频超声弹性成像参数弹性应变率、弹性评分及血清TgAb、sIL-2R联合诊断甲状腺恶性结节的AUC为0.931,敏感度为90.32%,特异度为82.69%,约登指数为0.730,优于各参数及血清指标单独诊断价值(P<0.05)。结论:高频超声弹性成像参数联合血清TgAb、sIL-2R水平对甲状腺结节性质具有一定鉴别诊断价值,可作为临床鉴别诊断结节性质的有效检查方案之一。
Objective:To investigate the value of high frequency ultrasound elastic imaging parameters combined with serum anti-thyroglobulin antibody(TgAb)and soluble interleukin-2 receptor(sIL-2R)levels in differential diagnosis of thyroid nodule properties.Methods:A total of 83 patients with thyroid nodules admitted to our hospital from Jun 2021 to Jun 2023 were selected.All of them were examined by high-frequency ultrasound elastography.According to fine needle puncture or postoperative pathological results,the patients were included in the benign group(52 cases)and the malignant group(31 cases),respectively.The imaging characteristics,high-frequency ultrasound elastography parameters(elastic strain rate,elasticity score)and serum TgAb and sIL-2R levels of the 2 groups were compared,and the diagnostic value of the combined application for malignant thyroid nodules were analyzed.Results:The proportion of uneven echo,irregular morphology,perforating vessels,unclear boundaries,and gravel-like calcification in the malignant group was higher than that in the benign group(P<0.01).The elastic strain rate,elastic score,and serum TgAb and sIL-2R levels in the malignant group were higher than those in the benign group(P<0.01).The AUC of the combined diagnosis of thyroid malignant nodules with elastic strain rate,elastic score,and serum TgAb and sIL-2R was 0.931,with a sensitivity of 90.32%,a specificity of 82.69%,and a Youden index of 0.730,which were superior to the diagnostic value of each indicator alone(P<0.05).Conclusion:High frequency ultrasound elastic imaging parameters combined with serum TgAb and sIL-2R levels have a certain value in differential diagnosis of thyroid nodule properties,and can be used as one of the effective diagnostic methods for differential diagnosis of thyroid nodule properties.
作者
姚娟
张悦
王燕铭
YAO Juan;ZHANG Yue;WANG Yanming(Department of Ultrasound Medicine,Zhoukou Orthopaedic Hospital,Zhoukou 466000,China;Department of Ultra-sound,Zhoukou Maternal and Child Health Hospital(Zhoukou Children's Hospital;Department of Ultrasound,South Tai-hu Hospital Affiliated to Huzhou University)
出处
《沈阳医学院学报》
2025年第1期43-47,共5页
Journal of Shenyang Medical College
基金
河南省医学科技攻关联合共建项目(No.LHGJ20219451)。
关键词
高频超声弹性成像
抗甲状腺球蛋白抗体
可溶性白介素-2受体
甲状腺结节
鉴别诊断
high-frequency ultrasonic elastography
anti-thyroglobulin antibody
soluble interleukin-2 receptor
thyroid nodules
differential diagnosis
