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溃疡性结肠炎患者炎症发生和持续时间与血小板计数增加的关系

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摘要 溃疡性结肠炎为慢性炎症性肠道疾病,病程中会反复出现血小板计数增多,有增加冠状动脉疾病风险、维持炎症状态、放大炎症反应等危害。目前对于是否采取治疗措施无明确规定。血小板(PLT)计数增加不仅归因于炎症,还与缺铁、维生素D缺乏、趋化因子受体5(CCR5)的趋化因子配体5(CCL5)信号传导、血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)、基质金属蛋白酶(MMP-9)等因素相关。除了传统的刺激巨核细胞增生的细胞因子白介素(IL)-2、IL-11、IL-4、IL-6、IL-1β、IL-8等,有多种因素可能成为血小板计数增多的替代过程。
出处 《当代医药论丛》 2025年第4期24-27,共4页 Contemporary Medical Symposium
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