摘要
慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)是一种普遍存在的慢性炎症性肺部疾病,以气流受限和不完全可逆性为特征。COPD的发病机制复杂,包括炎症反应、氧化应激、蛋白酶与抗蛋白酶失衡等。血清白蛋白(albumin, ALB)及其衍生生物标志物作为营养状态和炎症反应的生物指标,对COPD的发病机制、病情评估及预后判断有重要作用。目前,国内外尚无COPD与ALB及其衍生生物标志物的系统性阐述,本文通过综合分析最新的研究成果,增强读者对这些生物标志物在COPD中作用的理解,并揭示其潜在的研究价值。
Chronic obstructive pulmonary disease(COPD)is a widespread chronic inflammatory lung disease characterized by airflow limitation and partial irreversibility.The pathogenesis of COPD is complex,involving inflammatory responses,oxidative stress,and proteases anti-proteases imbalance.Serum albumin(ALB)and its derivative biomarkers,as bioindicators of nutritional status and inflammatory response,play an important role in the pathogenesis,disease assessment,and prognosis of COPD.At present,no comprehensive review on the relationship between COPD and serum albumin and its derivative biomarkers has been published.This review synthesizes the latest research findings to deepen our understanding of the role of these biomarkers in COPD and to highlight their potential research value.
作者
付颖
熊阳阳
方思
李传香
郭红荣
Fu Ying;Xiong Yangyang;Fang Si;Li Chuanxiang;Guo Hongrong(Department of Medicine,Wuhan University of Science and Technology,Wuhan 430081,China;Department of Respiratory and Critical Care Medicine,Wuhan Third Hospital and Tongren Hospital Affiliated to Wuhan University,Wuhan 430060,China)
出处
《中国防痨杂志》
北大核心
2025年第2期231-236,共6页
Chinese Journal of Antituberculosis
基金
武汉市预防医学科研专项基金(WY22A08)。
关键词
肺疾病
慢性阻塞性
血清白蛋白
生物学标记
综述文献(主题)
Pulmonary disease
chronic obstructive
Serum albumin
Biological markers
Review literature as topic
