摘要
目的:探讨肥胖型多囊卵巢综合征(PCOS)不孕患者血清铁蛋白(SF)和转铁蛋白(TRF)评估体外受精-胚胎移植(IVF-ET)助孕结局价值。方法:回顾性收集2021年8月-2023年12月本院就诊的PCOS不孕症患者78例临床资料,根据体质指数(BMI)分为肥胖组(n=48)和非肥胖组(n=30)。患者均行IVF-ET,按是否妊娠分为妊娠失败组28例和妊娠成功组50例。免疫比浊法检测血清SF和TRF水平。计算稳态模型胰岛素抵抗指数(HOMA-IR),采用Spearman相关系数分析PCOS不孕症患者血清SF、TRF水平与HOMA-IR的相关性。构建受试者工作特征(ROC)曲线分析血清SF、TRF水平预测PCOS患者IVF-ET妊娠结局价值。结果:肥胖组SF(7.58±1.82 ng/ml)、TRF(16.53±2.81μg/ml)、HOMA-IR(3.39±0.94)水平均高于非肥胖组(5.28±0.96 ng/ml、11.65±1.53μg/ml、2.06±0.49);Spearman相关性分析,血清SF、TRF水平与HOMA-IR存在正相关,妊娠失败组SF、TRF、HOMA-IR水平均高于妊娠成功组(均P<0.05)。血清SF联合TRF预测PCOS不孕症患者妊娠失败的曲线下面积为0.925,灵敏度82.1%,特异度90.0%。结论:PCOS不孕症患者血清SF和TRF异常升高,联合预测IVF-ET助孕结局效能较高。
Objective: To explore the value of the levels of the serum ferritin(SF) and transferring(TRF) of infertile patients with obese polycystic ovary syndrome(PCOS) for evaluating their fertility outcomes after in vitro fertilization-embryo transfer(IVF-ET). Methods: The clinical data of 78 infertile patients with PCOS who visited the hospital from August 2021 to December 2023 were selected as research subjects. Based on the body mass index(BMI) of the patients, these patients were divided into group A(48 cases with obese) and group B(30 cases without obese). All these patients were given the treatment of IVF-ET, and these patients were divided into two groups, including 28 cases with failure of pregnancy in group C and 50 cases with pregnancy success in group D. The levels of SF and TRF of the infertile patients were measured by immunoturbidimetric method. The homeostatic model assessment for insulin resistance(HOMA-IR) value of the patients was calculated. The correlation between the serum SF and TRF levels of the infertile patients with PCOS and their HOMA-IR value was analyzed by Spearman correlation coefficient. Receiver operating characteristic(ROC) curve was constructed to predict the value of the serum SF and TRF levels of the infertile patients with PCOS for their pregnancy outcomes. Results: The levels of SF(7.58±1.82 ng/ml) and TRF(16.53±2.81μg/ml), and the HOMA-IR value(3.39±0.94) of the patients in group A were significantly higher than those(5.28±0.96 ng/ml, 11.65±1.53μg/ml and 2.06±0.49) of the patients in group B. Spearman correlation analysis showed that the serum SF and TRF levels of the patients were positively correlated with their HOMA-IR value.The levels of SF and TRF,and the HOMA-IR of the patients in group C were significantly higher than those of the patients in group D(all P<0.05).The area under the curve,the sensitivity and the specificity of the serum SF level combined with the TRF level of the infertility patients with PCOS for predicting their pregnancy failure were 0.925,82.1% and90.0%,respectively.Conclusion:The levels of the serum SF and TRF of the infertility patients with PCOS are abnormally increased,and the combination of the SF and TRF levels has the higher efficacy for predicting the outcomes of IVF-ET of the patients.
作者
刘欣
何金林
梁婷
罗恒
LIU Xin;HE Jinlin;LIANG Ting;LUO Heng(Nanchong Fifth People's Hospital,Nanchong,Sichuan Province,637100;The First Affiliated Hospital of Air Force Medical University,People's Liberation Army of China,Xian,Shanci Province)
出处
《中国计划生育学杂志》
2025年第2期387-391,共5页
Chinese Journal of Family Planning
关键词
肥胖型多囊卵巢综合征
体外受精-胚胎移植
血清铁蛋白
转铁蛋白
胰岛素抵抗指数
妊娠结局
预测
Obese polycystic ovary syndrome
In vitro fertilization-embryo transfer
Serum Ferritin
Transferrin
Ho-meostatic model assessment for insulin resistance
Pregnancy outcomes
Prediction
