摘要
目的:探究肥胖型多囊卵巢综合征(PCOS)患者孕早期血清触珠蛋白(Hp)、脂肪酸结合蛋白(FABP)水平及与不良妊娠结局关系。方法:收集2021年7月-2023年1月本院收治的本院诊治的PCOS患者,其中肥胖型(体质指数≥28 kg/m2)孕妇143例作为肥胖组,非肥胖型孕妇55例作为对照组。根据妊娠结局将肥胖组分成不良组(n=46)和良好组(n=97)。使用酶联免疫吸附试验检测并比较各组孕早期血清Hp、FABP水平;对不同妊娠结局的肥胖型PCOS患者血清Hp、FABP水平进行Spearman相关性分析、多因素logistic回归分析和受试者工作特征(ROC)曲线分析。结果:孕早期肥胖组血清Hp(1.41±0.49 mg/ml)、FABP(5.35±1.13 ng/ml)水平均高于非肥胖组(0.82±0.43 mg/ml、3.86±0.54 ng/ml),肥胖组妊娠不良组血清Hp、FABP水平高于良好组(均P<0.05);肥胖组血清Hp、FABP水平与不良妊娠均呈正相关性,血清Hp、FABP水平升高是PCOS患者发生不良妊娠的独立危险因素(均P<0.05);ROC曲线分析,Hp、FABP的截点值分别为1.742mg/ml和5.312ng/ml,血清Hp、FABP水平以及二者联合预测不良妊娠的曲线下面积值为0.678、0.827、0.855,联合检测的灵敏度0.783和特异度0.855。结论:孕早期肥胖型PCOS患者血清Hp、FABP水平显著升高,其水平与发生不良妊娠呈正相关性,检测血清Hp、FABP水平对预测肥胖型PCOS患者不良妊娠结局有较好临床指导价值。
Objective: To investigate the correlation between the serum haptoglobin(Hp) and fatty acid binding protein(FABP) levels of pregnant women with obese polycystic ovary syndrome(PCOS) during the first trimester of pregnancy and their adverse pregnancy outcomes. Methods: 143 pregnant women with obese PCOS who had admitted to the hospital from July 2021 to January 2023 were selected in group A, and 55 pregnant women without obese were selected in group B during the same period. The women in group A were divided into group A1(46 women with adverse pregnancy outcomes) and group A2(97 women with normal pregnancy outcomes) according to their pregnancy outcomes. The serum Hp and FABP levels of the women in these groups were detected by enzyme linked immunosorbent assay(ELISA). Spearman correlation analysis, multivariate logistic regression analysis and receiver operating characteristic(ROC) curve analysis were performed to explore the serum Hp and FABP levels of the women in group A1 and group A2. Results: The levels of serum Hp(1.41±0.49 mg/ml) and FABP(5.35±1.13 ng/ml) of the women in group A were significantly higher than those(0.82±0.43 mg/ml and 3.86±0.54 ng/ml) of the women in group B. The levels of serum Hp and FABP of the women in group A1 were significantly higher than those of the women in group A2(all P<0.05). The serum Hp and FABP levels of the women in group A were positively correlated with their adverse pregnancy outcomes.The increased serum Hp and FABP levels of the women in group A were the independent risk factors of their adverse pregnancy outcomes(all P<0.05).ROC curve analysis showed that the cut-off values of the Hp and FABP levels of the women in group A for predicting their adverse pregnancy outcomes were 1.742mg/ml and 5.312ng/ml.The area under the curve of the serum Hp level,the serum FABP level and the combination serum Hp and FABP levels of the women in group A for predicting their adverse pregnancy outcomes were 0.678,0.827and0.855,respectively.The sensitivity and the specificity of the combination of the serum Hp and FABP levels of the women in group A for predicting their adverse pregnancy outcomes were 0.783and 0.855.Conclusion:The serum Hp and FABP levels of the pregnant women with obese PCOS during the first trimester of pregnancy increase significantly,and which are significantly positive correlations with the adverse pregnancy outcomes of the women.The detections of the serum Hp and FABP levels of the pregnant women with obese PCOS has important clinical guilding values for predicting their adverse pregnancy outcomes.
作者
王璇
綦萍
刘钦文
WANG Xuan;QI Ping;LIU Qinwen(Jiaozhou Central Hospital,Qingdao,Shandong Province,266300)
出处
《中国计划生育学杂志》
2025年第2期376-380,共5页
Chinese Journal of Family Planning
基金
青岛市医疗卫生重点学科建设项目资助。
关键词
肥胖型多囊卵巢综合征
妊娠早期
触珠蛋白
脂肪酸结合蛋白
不良妊娠
影响因素
预测
Obese polycystic ovary syndrome
The first trimester of pregnancy
Haptoglobin
Fatty acid binding protein
Adverse pregnancy
Influence factor
Prediction
