摘要
目的:探讨联合参附注射液与小剂量糖皮质激素治疗感染性休克的临床效果。方法:于2021年1月至2023年12月期间,纳入南平市第一医院感染性休克患者80例开展对照研究,采取随机数字表法分为两组:对照组(40例,给予常规治疗);观察组(40例,给予参附注射液联合小剂量糖皮质激素治疗)。比较两组患者治疗前后的炎症因子和血液乳酸水平、血流动力学和免疫功能指标及血管活性药物使用时间和临床疗效。结果:治疗后,观察组患者的白细胞介素–6(IL–6)、肿瘤坏死因子–α(TNF–α)、血液乳酸水平、血流动力学指标及免疫功能指标均优于对照组,且血管活性药物使用时间缩短,临床总有效率高于对照组,差异均具有统计学意义(P<0.05)。结论:感染性休克患者接受参附注射液联合小剂量糖皮质激素治疗后,其体内炎症因子水平明显下降,且该疗法可有效改善患者组织的灌注与氧合状况,对其免疫功能有良好的调节作用。
Objective Exploring the clinical efficacy of combined Shenfu injection and low-dose glucocorticoids in the treatment of septic shock.Methods From January 2021 to December 2023,a comparative study was conducted on 80 patients with septic shock from the First Hospital of Fujian Nanping.They were randomly divided into two groups using a random number table method:a control group (40 cases,receiving conventional treatment);and an observation group (40 cases,treated with Shenfu injection combined with low-dose glucocorticoids).Compare the inflammatory factors,blood lactate levels,hemodynamic and immune function indicators,as well as the duration and clinical efficacy of vasoactive drug use between two groups of patients before and after treatment.Results After treatment,the interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α),blood lactic acid level,hemodynamic indexes and immune function indexes in the observation group were better than those in the control group,and the use time of vasoactive drugs was shortened,and the total clinical effective rate was higher than that in the control group,with statistical significance (P < 0.05).Conclusion After receiving Shenfu injection combined with low-dose glucocorticoid therapy,the level of inflammatory mediators in the patients with septic shock decreased significantly,and the therapy can effectively improve the perfusion and oxygenation status of the patients' tissues,and has a good regulation effect on their immune function.
作者
杨正光
徐璐茜
周钦伟
YANG Zhengguang;XU Luxi;ZHOU Qinwei(The First Hospital of Fujian Nanping,Fujian Nanping 353099)
出处
《深圳中西医结合杂志》
2024年第19期24-27,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
