摘要
本文采用不同剂量伊曲康唑间歇冲击疗法治疗２２例甲真菌病患者，并用高压液相色谱法（ＨＰＬＣ）测定了伊曲康唑在甲板中的浓度。结果表明：４００，３００，２００ｍｇ·ｄ－１三个不同剂量组，服药后１周即可在指、趾甲远端测出药物，停药后６个月仍可在甲板中测到高于ＭＩＣ的浓度。证明药物进入甲板有两条途径：一是通过甲床迅速弥散；二是与甲母细胞结合后进入。药物进入指甲的速度较进入趾甲为快，甲板中药物的浓度与口服药物的剂量呈正相关，４００ｍｇ组明显高于２００ｍｇ组。
Twenty-two patients with onychomycosis were treated with Itraconazole intermittent pulse therapy dosed 200mg, 300mg and 400mg either for 2 or 3 cycles. The distal nail clippings were taken before initiation of therapy and 0.25,1,2,3,4,5,6,7,8,9(toenail only) months there after. The concentration of itraconazole in the nail plates were measured by HPLC assay. Therapeutic concentration of itraconazole can be detected in different dosage groups both in fingernail and toenail plates in the first week after the onset of treatment. Itraconazole could be detected in the nail until 6 months after the end of treatment. The data suggest that the drug reaches the nail via incorporation into the matrix and by diffusion from the nail bed and is eliminated with regrowth of the nail after discontinuation of treatment. The drug concentration measured at all time points are well above the MICs for dermatophytes and other fungi . These data show that itraconazole reaches the nail plate rapidly and persists there for longer time after the stop of treatment. The concentration of itraconazole in nail plate is related to the drug dose.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1998年第2期99-103,共5页
The Chinese Journal of Clinical Pharmacology
