摘要
目的 观察益肝煎剂抗肝纤维化的临床疗效 ,并探讨其抗肝纤维化机制。方法 将 45例慢性肝病肝纤维化患者随机分为 2组 ,治疗组 30例 ,口服益肝煎剂 ,每次 1袋 ,每日 2次温服。对照组 1 5例 ,口服强肝胶囊 ,每次 6粒 ,每日 2次。 2组均 90日为 1个疗程。观察治疗前后血清透明质酸 (HA)、Ⅲ型前胶原 (PCⅢ ) ,层粘连蛋白 (LN)、Ⅳ型胶原 (ⅣC)、丙氨酸氨基转移酶 (ALT)变化。结果 治疗组总有效率为 93.33% ,对照组总有效率为 86.67% ,2组比较有显著性差异 (P <0 .0 5 )。 2组治疗后血清PCⅢ、LN水平比较有显著性差异(P <0 .0 5 ) ;而血清HA、ⅣC、ALT水平比较无显著性差异 (P >0 .0 5 )。结论 益肝煎剂有良好抗肝纤维化作用 ,其作用机制可能与其保护肝细胞。
Objective To investigate the therapeutic effect of Yigan decoction on hepatic fibrosis and research its mechanism.Methods 45 patients with hepatic fibrosis caused by clinical hepatic disease were randomly divided into two groups. In the treatment group (n=30) Yigan decoction was orally taken, one bag once, two times a day; in the control group (n=15) Qianggan capsule was orally taken, six tablets once, twice a day, with a treatment course of ninety days for both groups.The levels of HA,PCⅢ,LN, ⅣC and ALT were tested.Results The total effective rate was 93.33% in the treatment group and 86.67% in the control group, there was significant difference between the two groups (P<0.05) . The effects of the treatment group on reducing the levels of PCⅢ and LN were more obvious than that of the control group (P<0.05), while the effects on reducing the serum levels of HA, ⅣC and ALT were not obvious (n>0.05).Conclusion Yigan decoction had affirmative effect on treating liver fibrosis .The mechanism may be relative to protecting cells of liver, decreasing collagen synthesis and increasing collagen disintegration.
出处
《河北中医》
2002年第11期808-810,共3页
Hebei Journal of Traditional Chinese Medicine
基金
河北省中医药管理局科技攻关项目
编号 :980 13
关键词
肝纤维化
血清学指标
益肝煎剂
疗效
Hepatic fibrosis
Serotogic indicator
Yigan decoction
