摘要
目的探究蒙药那如-3味丸对普瑞巴林联合神经阻滞治疗神经病理性疼痛(NP)效果的影响。方法选择2022年10月至2023年9月确诊为NP的疼痛科住院患者41例,男20例,女21例,年龄40~80岁,BMI≥18.5 kg/m^(2)。采用随机数字表法将患者分为两组:蒙药那如-3味丸组(观察组,n=20)和常规治疗组(对照组,n=21)。对照组为常规治疗,口服普瑞巴林胶囊联合超声引导下疼痛区域神经阻滞;观察组在常规治疗的基础上增加蒙药那如-3味丸(2 g/10粒),每晚临睡前口服3~5粒,共2周。记录治疗前1 d、治疗后2周、1个月、2个月数字评分量表(NRS)疼痛评分、简化McGill疼痛问卷(SF-MPQ)评分、匹兹堡睡眠质量指数(PSQI)。分别于治疗前1 d、治疗后2周采用ELISA法检测血清IL-6、IL-8、IL-1β、TNF-α浓度。记录治疗期间不良反应的发生情况,如恶心、呕吐、腹胀、心悸、嗜睡和头晕等。结果与治疗前1 d比较,治疗后2周、1个月、2个月两组NRS疼痛评分、SF-MPQ评分、PSQI均明显降低(P<0.05);治疗后2周两组血清IL-6、IL-1β、TNF-α浓度明显降低(P<0.05)。与对照组比较,治疗后2周、1个月、2个月观察组NRS疼痛评分、SF-MPQ评分、PSQI均明显降低(P<0.05);治疗后2周观察组IL-6、IL-1β、TNF-α浓度明显降低(P<0.05)。两组不良反应发生率差异无统计学意义。结论蒙药那如-3味丸联合常规疗法可有效减轻NP患者的疼痛,改善患者的睡眠质量,且可能具有调节神经炎症作用。
Objective To explore the effect of Mongolian medicine Naru-3 pills on the treatment of neuropathic pain(NP)with pregabalin combined with nerve block.Methods Forty-one hospitalized patients in the department of pain medicine diagnosed with NP from October 2022 to September 2023 were selected,including 20 males and 21 females,aged 40-80 years,BMI≥18.5 kg/m^(2).The patients were divided into two groups by random number table method:Mongolian medicine Naru-3 pills group(observation group,n=20)and conventional treatment group(control group,n=21).The control group received conventional treatment:oral pregabalin capsule combined with ultrasound-guided nerve block in pain area.The observation group was added oral administration of Mongolian medicine Naru-3 pills(2 g/10 capsules)on the basis of conventional treatment,taking 3-5 capsules orally before going to bed every night for 2 weeks.The numerical rating scale(NRS)pain score,short-form McGill pain questionnaire(SF-MPQ)score,and Pittsburgh sleep quality index(PSQI)were recorded before treatment and 2 weeks,1 month,and 2 months after the treatment.The serum concentrations of IL-6,IL-8,IL-1β,and TNF-αwere detected by enzyme-linked immunosorbent assay(ELISA)1 day before treatment and 2 weeks after treatment.Occurrence of adverse reactions during treatment such as nausea,vomiting,bloating,palpitations,drowsiness,and dizziness were recorded.Results Compared with 1 day before treatment,NRS pain score,SF-MPQ score,and PSQI were lower in both groups 2 weeks,1 month,and 2 months after the treatment(P<0.05),the serum concentrations of IL-6,IL-1β,and TNF-αwere reduced in both groups 2 weeks after the treatment(P<0.05).Compared with the control group,NRS pain score,SF-MPQ score,and PSQI were lower in the observation group 2 weeks,1 month,and 2 months after the treatment(P<0.05);the serum concentrations of IL-6,IL-1β,and TNF-αwere reduced in the observation group 2 weeks after the treatment(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Mongolian Naru-3 pills combined with conventional therapy can effectively reduce the pain of NP patients,improve the quality of sleep of patients,and may have the effect of regulating neuroinflammation.
作者
越娜
澈力木格
李辉
吕亮亮
郎海云
铁植
都义日
YUE Na;CHE Limuge;LI Hui;LYU Liangliang;LANG Haiyun;TIE Zhi;DU Yiri(Department of Anesthesiology,Compass Department of Ordos Central Hospital,Ordos 017000,China)
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2024年第10期1068-1072,共5页
Journal of Clinical Anesthesiology
基金
高等学校青年科技英才支持计划(NJYT22020)
内蒙古自治区卫生健康科技计划项目(202201244)
内蒙古医科大学蒙药学“一流学科”引进培育人才科研项目(ylxkyjrc2021-02)。
