摘要
目的比较盐酸羟考酮与普瑞巴林对晚期结直肠癌(CRC)癌痛的治疗效果及安全性。方法选取2023年3月至2024年12月蒙自市人民医院收治的晚期CRC癌痛患者150例,采用随机数表法分为羟考酮组75例和普瑞巴林组75例。比较两组疗效、疼痛评分、不良反应发生情况以及生活相关指标。结果两组总有效率比较,差异无统计学意义(90.67%vs 86.67%,P>0.05);治疗后,羟考酮组患者数字等级评定量表评分显著低于普瑞巴林组,差异有统计学意义[(4.67±1.32)分vs(5.14±1.44)分,P<0.05];羟考酮组便秘、恶心呕吐比例显著高于普瑞巴林组,头晕嗜睡、外周水肿比例显著低于普瑞巴林组,差异有统计学意义(32.00%vs 6.67%,P<0.05;28.00%vs 14.67%,P<0.05;12.00%vs 25.33%,P<0.05;1.33%vs 12.00%,P<0.05);羟考酮组欧洲癌症研究与治疗组织生活质量核心量表C30躯体功能、匹兹堡睡眠质量指数量表、医院焦虑抑郁量表-焦虑评分显著高于普瑞巴林组,差异有统计学意义(P<0.05)。结论针对晚期CRC患者,盐酸羟考酮与普瑞巴林对内脏痛及神经病理性痛均有明确的效果,但两药在不良反应以及躯体、心理、睡眠的影响方面存在一定差异,临床需结合实际进行选择。
Objective To compare the efficacy and safety of oxycodone hydrochloride and pregabalin in treating advanced colorectal cancer(CRC)pain.Methods A total of 150 patients with advanced CRC pain admitted to the People's Hospital of Mengzi from March 2023 to December 2024 were selected.They were divided into the oxycodone group(75 cases treated with oxycodone hydrochloride sustained-release tablets)and the pregabalin group(75 cases treated with pregabalin capsules)using the random number table method.The efficacy,adverse reactions,and life-related indexes were compared between the two groups.Results There was no statistically significant difference in the overall effective rate between the two groups(90.67%vs 86.67%,P>0.05).After treatment,the numeric rating scale scores of the oxycodone group were significantly lower than those of the pregabalin group,and the differences were statistically significant[(4.67±1.32)points vs(5.14±1.44)points,P<0.05].The proportion of constipation,nausea and vomiting were significantly higher in the oxycodone group than in the pregabalin group,while the proportion of dizziness and lethargy and peripheral edema were significantly lower in the oxycodone group than in the pregabalin group,with statistically significant differences(32.00%vs 6.67%,P<0.05;28.00%vs 14.67%,P<0.05;12.00%vs 25.33%,P<0.05;1.33%vs 12.00%,P<0.05).The European Organization for Research and Treatment of Cancer quality of life questionnaire-core 30 score for physical function,Pittsburgh sleep quality index and hospital anxiety and depression scale-anxiety scores of the oxycodone group were significantly higher than those of the pregabalin group,with statistically significant differences(P<0.05).Conclusion For patients with advanced CRC,oxycodone hydrochloride and pregabalin can effectively treat visceral pain and neuropathic pain,respectively.However,there are certain differences in adverse reactions,physical dimension,psychological dimension,and sleep between the two drugs.In clinical practice,the drug should be chosen based on the actual condition.
作者
黄惠琼
陈应英
杨婧
徐婵
谢学丽
HUANG Huiqiong;CHEN Yingying;YANG Jing;XU Chan;XIE Xueli(Department of Oncology,The People's Hospital of Mengzi,Mengzi,Yunnan 661100,China)
出处
《转化医学杂志》
2025年第6期141-145,共5页
Translational Medicine Journal
基金
云南省科技厅科技计划项目(202401AT070015)。
关键词
晚期结直肠癌
癌痛
盐酸羟考酮
普瑞巴林
不良反应
Advanced colorectal cancer
Cancer pain
Oxycodone hydrochloride
Pregabalin
Adverse reaction
