摘要
我国是肝病大国,普及抗肝炎病毒药物是我国一种有效传染病防治手段,使传染性肝炎发病例持续下降,但随着人们的生活水平的不断提高,肥胖、糖尿病和过量饮酒引起的肝病发病率急剧上升,预计未来10~20年酒精性或由肥胖引起的肝病,将取代病毒性肝病成为影响人民健康的主要病因。酒精导致的酒精性肝病(ALD)长期并未受到应有的重视,国家在投入和研究水平仍急需加强。近年来,随着功能活性肽的预防和治疗酒精性肝病的潜在疗效越来越受到人们的重视。该文就近年来功能活性肽在预防和治疗酒精性肝损伤方面的研究做一综述,分析乙醇在体内的代谢途径,阐述酒精性肝损伤的发病机制,解析功能活性肽防治酒精性肝损伤的作用机理,为防治酒精性肝损伤功能性活性肽的开发提供科学依据。
China is a large country of liver diseases,the popularization of anti-hepatitis virus drugs is an effective means of infectious disease prevention and treatment in China,which makes the incidence of infectious hepatitis continue to decline.However,with the continuous improvement of people's living standards,the incidence rate of liver diseases caused by obesity,diabetes and excessive drinking has risen sharply.It is expected that liver diseases induced by alcoholic or obesity will replace viral liver diseases as the main cause of affecting people's health in the next 10 to 20 years.Alcoholic liver disease(ALD)caused by alcohol has not been paid due attention for a long time,and the national investment and research level still need to be strengthened.In recent years,the potential efficacy of functional peptides in the prevention and treatment of alcoholic liver disease has attracted extensive attention.The research on the prevention and treatment of alcoholic liver injury with functional active peptides in recent years was reviewed,the metabolic pathway of ethanol in the body was analyzed,and the pathogenesis of alcoholic liver injury was explained,the mechanism of functional active peptides for preventing and treating alcoholic liver injury was analyzed,and scientific basis for the development of functional active peptides for preventing and treating alcoholic liver injury was provided.
作者
何林枫
罗涛
王聪
汤雯迪
HE Linfeng;LUO Tao;WANG Cong;TANG Wendi(Hotel Department of Nanchong Vocational College of Culture and Tourism,Nanchong 637400,China;School of Food Science,Sichuan Agricultural University,Ya'an 625000,China)
出处
《中国酿造》
CAS
北大核心
2024年第8期20-23,共4页
China Brewing
基金
四川省科技厅重点研发项目(2020YFN0147)
南充文化旅游职业学院2022年度教学改革研究项目(JG2022A12)。
关键词
功能活性肽
酒精性肝损伤
氧化应激
炎症反应
functional active peptide
alcoholic liver injury
oxidative stress
inflammatory respons
