摘要
目的探讨血尿酸(BUA)、血脂水平与帕金森病(PD)的相关性。方法选取2021年7月-2023年7月安徽医科大学附属宿州医院神经内科住院及门诊≥45岁的PD患者96例作为PD组,另选取100例相同年龄组的健康体检人员作为对照组,比较PD组与对照组外周血TC、TG、HDL-C、LDL-C、BUA、ApoA、ApoB水平,并采用二元多因素Logistic回归分析BUA及血脂水平与PD患病风险的关系。结果PD组TG、HDL-C、BUA、ApoA水平均低于对照组(P<0.05)。二元多因素Logistic回归分析显示,BUA、TG、HDL-C、ApoA是PD的保护性因素,年龄为危险因素(P<0.05)。ROC曲线分析显示,BUA曲线下面积为0.611,灵敏度为54.20%,特异度为63.00%;TG曲线下面积为0.685,灵敏度为84.40%,特异度为44.00%;HDL-C曲线下面积为0.632,灵敏度为46.90%,特异度为75.00%;ApoA曲线下面积为0.646,灵敏度为41.70%,特异度为83.00%;年龄曲线下面积为0.672,灵敏度为80.20%,特异度为54.00%。结论PD患者BUA及血脂较正常对照组减低,且BUA、TG、HDL-C、ApoA、年龄与PD发病密切相关。
Objective To investigate the correlation between blood uric acid(BUA),blood lipid levels and Parkinson's disease(PD).Methods From July 2021 to July 2023,96 PD patients aged≥45 years in the Department of Neurology,Suzhou Hospital of Anhui Medical University were selected as PD group,and 100 healthy people in the same age group were selected as control group.The levels of TC,TG,HDL-C,LDL-C,BUA,ApoA and ApoB in peripheral blood of PD group and control group were compared,and the relationship between BUA and blood lipid levels and the risk of PD was analyzed by binary multivariate Logistic regression.Results The levels of TG,HDL-C,BUA,ApoA in the PD group were lower than those in the control group(P<0.05).Binary multivariate Logistic regression analysis showed that BUA,TG,HDL-C and ApoA were protective factors for PD,and age was a risk factor(P<0.05).ROC curve analysis showed that the area under the BUA curve was 0.611,the sensitivity was 54.20%,and the specificity was 63.00%;the area under the TG curve was 0.685,the sensitivity was 84.40%,and the specificity was 44.00%;the area under the curve of HDL-C was 0.632,the sensitivity was 46.90%,and the specificity was 75.00%;the area under the curve of ApoA was 0.646,the sensitivity was 41.70%,and the specificity was 83.00%;the area under the age curve was 0.672,the sensitivity was 80.20%,and the specificity was 54.00%.Conclusion BUA and blood lipid in PD patients are lower than those in normal control group,while BUA,TG,HDL-C,ApoA and age are closely related to the pathogenesis of PD.
作者
蒋凯丽
钟平
JIANG Kai-li;ZHONG Ping(Department of Neurology,Suzhou Hospital of Anhui Medical University,Suzhou 234000,Anhui,China)
出处
《医学信息》
2024年第13期80-84,共5页
Journal of Medical Information
基金
2022年安徽省卫生健康科研项目(编号:AHWJ2022b106)。
关键词
帕金森病
血尿酸
血脂
Parkinson's disease
Blood uric acid
Blood lipid
