摘要
目的 分析基于性别及发病年龄在中国南方帕金森病(PD)患者中的临床特征。方法 选择2017—2019年广东省第二人民医院收治的PD患者1 300例,其中男性739例,女性561例;早发型PD(EOPD)200例,晚发型PD(LOPD)1 100例,均完成各项量表测评。结果 (1)与男性PD患者相比,女性PD患者平均起病年龄更小,焦虑、抑郁、头痛等程度更严重,以震颤为首发症状的发生率更高,差异有统计学意义(P<0.05)。(2)与EOPD患者相比,LOPD患者平均起病年龄更大、病程更短,病程进展更快,发生便秘、性欲改变等比例明显增高,以僵硬为首发症状的发生率也更低,差异有统计学意义(P<0.05)。结论 在中国南方地区,不同发病年龄和性别在PD患者临床症状方面存在差异性。
Objective To analyse the clinical features of Parkinson′s disease(PD)patients in southern China based on gender and age of onset.Methods A total of 1300 PD patients[including 739 males and 561 females,and 200 early-onset PD(EOPD)patients and 1100 late-onset PD(LOPD)patients]were selected from Guangdong Second Provincial General Hospital during 2017 and 2019,all of whom completed the assessment of all the scales.Results(1)The female PD patients had a younger mean age of onset,more severe anxiety,more depression,and more headache,and a higher incidence of tremor as the first symptom compared with the male PD patients and the differences were significant(P<0.05).(2)The LOPD patients had an older mean age of onset,shorter disease duration,faster disease progression,significantly higher rates of constipation,significantly higher rates of libido changes,and a lower incidence of stiffness as the first symptom compared with the EOPD patients and the differences were significant(P<0.05).Conclusion In southern China,there are differences in the clinical symptoms of PD patients according to age of onset and gender.
作者
汤宏茵
廖香连
李桂花
TANG Hong-yin;LIAO Xiang-lian;LI Gui-hua(Department of Neurology,Guangdong Second Provincial General Hospital,Guangzhou 510317,China;Second Clinical Medical College,Southern Medical University,Guangzhou 510515,China)
出处
《中国临床新医学》
2022年第12期1117-1122,共6页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
基金
广东省自然基金-自由项目(编号:2018A030313649)。
关键词
帕金森病
发病年龄
性别
临床特征
Parkinson′s disease(PD)
Age of onset
Gender
Clinical feature
