摘要
非甾体抗炎药(NSAIDs)是治疗骨关节炎、类风湿关节炎和急慢性疼痛最常用的药物之一。在使用NSAIDs的患者中发现,NSAIDs的疗效在个体之间存在较大差异,这可能导致患者治疗失败或出现危及生命的药物不良反应。本综述从药物代谢酶CYP2C9基因多态性、环氧化酶基因多态性以及肠道微生物群差异的角度对引起NSAIDs疗效差异的原因进行分析讨论,为NSAIDs个体化用药方案的制定提供参考依据。
Nonsteroidal anti-inflammatory drugs(NSAIDs) are widely used to treat osteoarthritis,rheumatoid arthritis,and acute and chronic painful diseases.Significant interindividual heterogeneity in the efficacy of NSAIDs has been found in patients,which can lead to treatment failure or life-threatening adverse drug reactions.This review will discuss the causes of the variability in the efficacy of NSAIDs in terms of CYP2C9 enzyme gene polymorphism,cyclooxygenase enzyme gene polymorphism,and differences in the intestinal microbiota,to provide a reference for the development of individualized dosing regimens for NSAIDs.
作者
姑丽尼格尔·艾尼瓦尔
谢菡
陈心怡
马旭东
葛卫红
于锋
Gulinigeer·AINIWAER;XIE Han;CHEN Xinyi;MA Xudong;GE Weihong;YU Feng(Department of Pharmacy,China Pharmaceutical University Nanjing Drum Tower Hospital,Nanjing 210008,China;School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 210009,China;Department of Pharmacy,Nanjing Drum Tower Hospital Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China;Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing 210009,China)
出处
《中国药师》
CAS
2024年第5期885-891,共7页
China Pharmacist
基金
国家自然科学基金青年科学基金项目(72104105)
2023年度江苏省药品临床综合评价项目(苏卫办药政[2022]15号)。
关键词
非甾体抗炎药
疗效差异
药物代谢酶
CYP2C9
环氧化酶
肠道微生物群
骨关节炎
类风湿关节炎
基因多态性
Non-steroidal anti-inflammatory drugs
Differences in efficacy
Drug metabolizing enzymes
CYP2C9
Cyclooxygenase
Intestinal microbiota
Osteoarthritis
Rheumatoid arthritis
Gene polymorphism
