摘要
目的探讨鼻咽癌合并EB病毒感染外周血潜伏膜蛋白1(LMP-1)、p53、Ki67表达水平与疾病进展的相关性。方法选择2019年1月—2022年3月在西南医科大学附属医院肿瘤科确诊为鼻咽癌患者120例为研究对象,其中合并EB病毒感染患者85例纳入感染组,35例未感染患者纳入对照组,检测患者外周血LMP-1、p53、Ki67表达水平及其与鼻咽癌患者合并EB病毒感染临床特征的关系。结果感染组患者LMP-1、p53和Ki67阳性表达率均高于对照组(P<0.05);LMP-1、p53和Ki67阳性表达与性别、年龄、T分期、病理类型、临床分期、淋巴结转移无相关性,与N分期具有相关性(P<0.05),且N分期越高,阳性表达率越高(P<0.05),远处转移患者阳性表达率高于未远处转移患者(P<0.05)。结论鼻咽癌合并EB病毒感染患者外周血LMP-1、p53、Ki67阳性表达率升高,并与临床N分期、淋巴结远处转移具有相关性。
OBJECTIVE To explore the association between the expressions of latent membrane protein 1(LMP-1),p53 and Ki67 in peripheral blood of the nasopharyngeal carcinoma patients complicated with EB virus infection and the progression of disease.METHODS Totally 120 patients who were diagnosed with nasopharyngeal carcinoma in the Affiliated Hospital of Southwest Medical University from Jan 2019 to Mar 2022 were enrolled in the study,85 of whom were complicated with EB virus infection and were assigned as the infection group,and 35 were not com-plicated with infection and were assigned as the control group.The expression levels of peripheral blood LMP-1,p53 and Ki67 were detected,and the association between the above indexes and clinical characteristics of the naso-pharyngeal carcinoma patients complicated with EB virus infection was observed.RESULTS The positive rates of expressions of LMP-1,p53 and Ki67 of the infection group were higher than those of the control group(P<0.05).The positive expressions of LMP-1,p53 and Ki67 were not associated with gender,age,T stage,pathological type,clinical stage or lymphatic metastasis but were associated with N stage(P<0.05);the higher the N stage,the higher the positive rate of expression was(P<0.05);the positive rates of expressions of the pa-tients with distant metastasis were higher than those of the patients without distant metastasis(P<0.05).CONCLUSION The positive rates of expressions of peripheral blood LMP-1,p53 and Ki67 are elevated in the naso-pharynasopharyngeal carcinoma patients complicated with EB virus infection and were associated with the clinical N stage and lymphaticmetastasis.
作者
周雪
詹雨薇
武正菊
余钥
余威
张玉琴
ZHOU Xue;ZHAN Yu-wei;WU Zheng-ju;YU Yue;YU Wei;ZHANG Yu-qin(Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China;不详)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2024年第2期239-242,共4页
Chinese Journal of Nosocomiology
基金
四川省科研基金资助项目(2020LK03102)
西南医科大学青年基金资助项目(2019SQN015)
泸州市社会科学界联合会项目(JK-2022-58)。
